心肾综合征：病理生理学。
Cardiorenal Syndrome: Pathophysiology.
机构信息
Division of Nephrology-Hypertension, University of California San Diego, 9500 Gilman Drive# 9111H, La Jolla, CA 92093-9111, USA.
Division of Cardiology, University of California San Diego, 9434 Medical Center Drive, La Jolla, CA 92037, USA.
出版信息
Cardiol Clin. 2019 Aug;37(3):251-265. doi: 10.1016/j.ccl.2019.04.001. Epub 2019 May 21.
Abstract
Cardiorenal syndrome commonly refers to the collective dysfunction of heart and kidney resulting in a cascade of feedback mechanism causing damage to both the organs and is associated with adverse clinical outcomes. The pathophysiology of cardiorenal syndrome is complex, multifactorial, and dynamic. Improving the understanding of disease mechanisms will aid in developing targeted pharmacologic and nonpharmacologic therapies for the management of this syndrome. This article discusses the various mechanisms involved in the pathophysiology of the cardiorenal syndrome.
摘要
心脏肾综合征通常是指心脏和肾脏的共同功能障碍，导致一系列反馈机制，从而对两个器官造成损害，并与不良的临床结局相关。心脏肾综合征的病理生理学是复杂的、多因素的和动态的。改善对疾病机制的理解将有助于为该综合征的管理开发有针对性的药物和非药物治疗。本文讨论了心脏肾综合征病理生理学中涉及的各种机制。
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