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心脏手术后长期 HRQOL 的预测因素:一项 5 年随访研究。

Predictors of long-term HRQOL following cardiac surgery: a 5-year follow-up study.

机构信息

Clinic of Anaesthesiology and Intensive Care, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.

Centre for Psychotraumatology, Institute of Psychology, Vilnius University, Vilnius, Lithuania.

出版信息

Health Qual Life Outcomes. 2021 Aug 17;19(1):197. doi: 10.1186/s12955-021-01838-1.

Abstract

BACKGROUND

The study aimed to evaluate the long-term change of health-related quality of life (HRQOL) and to identify predictors of HRQOL 5 years after cardiac surgery.

METHODS

Consecutive adult patients, undergoing elective cardiac surgery were enrolled in the study. HRQOL was measured using the Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36) questionnaire before and 5-years after cardiac surgery. A multivariate latent change modeling approach was used for data analysis.

RESULTS

210 participants (30.5% female) were reached at 5-year follow-up and included in final data analysis. The study revealed, after controlling for gender effects, a significant long-term positive change, in physical functioning (PF, M = 19.79, p < 0.001), social functioning (SF, M = 17.27, p < 0.001), vitality (VT, M = 6.309, p < 0.001) and mental health (MH, M = 8.40, p < .001) in the total sample. Lower education was associated with an increase in PF (M = 24.09, p < 0.001) and VT (M = 8.39, p < 0.001), more complicated surgery (other than the coronary artery bypass graft (CABG) predicted increase in general health (GH, M = 6.76, p = 0.005). Arrhythmia was a significant predictor for lower pre- and post-operative VT and SF.

CONCLUSIONS

Overall HRQOL in our sample improved from baseline to five years postoperatively. Further studies including larger patient groups are needed to confirm these findings.

摘要

背景

本研究旨在评估心脏手术后 5 年健康相关生活质量(HRQOL)的长期变化,并确定 HRQOL 的预测因素。

方法

连续纳入接受择期心脏手术的成年患者进行研究。在心脏手术后 5 年,使用医疗结局研究 36 项简明健康调查(SF-36)问卷测量 HRQOL。采用多变量潜在变化建模方法进行数据分析。

结果

210 名参与者(30.5%为女性)在 5 年随访时达到并纳入最终数据分析。研究结果表明,在控制性别影响后,除女性外,生理功能(PF,M=19.79,p<0.001)、社会功能(SF,M=17.27,p<0.001)、活力(VT,M=6.309,p<0.001)和心理健康(MH,M=8.40,p<.001)均呈显著长期正向变化。受教育程度较低与 PF(M=24.09,p<0.001)和 VT(M=8.39,p<0.001)增加有关,更复杂的手术(非冠状动脉旁路移植术(CABG)预测一般健康(GH,M=6.76,p=0.005)增加。心律失常是预测术前和术后 VT 和 SF 降低的显著因素。

结论

本研究样本的总体 HRQOL 从基线到术后 5 年得到改善。需要进一步研究包括更大的患者群体来证实这些发现。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f811/8371845/3cbf4c4899ff/12955_2021_1838_Fig1_HTML.jpg

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