Handfield-Jones S E, Grattan C E, Simpson R A, Kennedy C T
Department of Dermatology, Bristol Royal Infirmary, U.K.
Br J Dermatol. 1988 Mar;118(3):425-7. doi: 10.1111/j.1365-2133.1988.tb02438.x.
In-patients with venous leg ulcers showed increased healing rates with a hydrocolloid dressing (Granuflex), as compared with a traditional paraffin gauze dressing (Jelonet), in a randomized sequential crossover trial, although the difference was not statistically significant. Bacteriological studies showed that the hydrocolloid dressing favoured growth of both aerobes and anaerobes in significantly greater numbers compared with paraffin gauze. Heavy bacterial colonization had no effect on the healing rates of the ulcers. Granuflex is said to produce an anaerobic environment--survival of Pseudomonas aeruginosa, a strict aerobe, under Granuflex dressings, makes this seem unlikely.
