School of Maritime Studies, Marine Institute, Memorial University St. John's, 155 Ridge Road, St. John's, Newfoundland, A1C 5R3, Canada; Department of Exercise Science and Sports Medicine, University of Cape Town, Private Bag, Rondebosch, 7700 South Africa.
School of Maritime Studies, Marine Institute, Memorial University St. John's, 155 Ridge Road, St. John's, Newfoundland, A1C 5R3, Canada.
Neurosci Biobehav Rev. 2019 Sep;104:197-208. doi: 10.1016/j.neubiorev.2019.06.021. Epub 2019 Jul 5.
Humans have a sophisticated set of neural structures for cutaneous thermoception. Sufficiently cold temperatures are thought to evoke pain and motivation to resolve disturbed homeostasis, while cool but not painful temperatures are evaluated as cold but do not cause thermoregulatory behaviour. Brain networks for innocuous and noxious cold temperature have been proposed but a quantitative meta-analysis comparing the two has never been conducted. As a result, we sought to perform activation likelihood estimation analysis of the brain activity associated with innocuous and noxious cold exposure. Combining data from 33 data sets revealed that innocuous cold exposure activates the posterior insular, middle/orbital and posterior parietal cortices while noxious cold activates the thalamus, putamen, and right anterior insula cortex. Both conditions respectively show greater activation in these areas and no areas are common between conditions. Our results confirm the long-standing hypothesis that noxious cold is encoded in the right anterior insula, but contradicts the selective importance of the posterior insula for cool somatosensory processing.
人类拥有一套复杂的皮肤温度感觉神经结构。人们认为，足够低的温度会引起疼痛，并促使机体努力恢复稳定状态，而凉爽但不引起疼痛的温度则被视为冷觉，但不会引起体温调节行为。人们已经提出了用于无害和有害冷温度的大脑网络，但从未进行过比较这两种温度的定量荟萃分析。因此，我们试图对与无害和有害冷暴露相关的大脑活动进行激活似然估计分析。结合来自 33 个数据集的数据表明，无害冷暴露激活了后岛叶、中/眶额和后顶叶皮质，而有害冷暴露则激活了丘脑、壳核和右侧前岛叶皮质。两种情况下这些区域的激活程度均较高，且两种情况下均无共同区域。我们的结果证实了有害冷觉编码于右侧前岛叶的长期假说，但与后岛叶对凉爽体感处理具有选择性重要性的观点相矛盾。
