Molecular Carcinogenesis Group, Department of Histology and Embryology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece.
Department of Anatomy, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Str., 11527 Athens, Greece.
Cells. 2019 Jul 6;8(7):686. doi: 10.3390/cells8070686.
Cellular senescence refers to a stress response aiming to preserve cellular and, therefore, organismal homeostasis. Importantly, deregulation of mitochondrial homeostatic mechanisms, manifested as impaired mitochondrial biogenesis, metabolism and dynamics, has emerged as a hallmark of cellular senescence. On the other hand, impaired mitostasis has been suggested to induce cellular senescence. This review aims to provide an overview of homeostatic mechanisms operating within mitochondria and a comprehensive insight into the interplay between cellular senescence and mitochondrial dysfunction.
细胞衰老指的是一种旨在维持细胞乃至整个生物体稳态的应激反应。重要的是，线粒体稳态机制的失调，表现为线粒体生物发生、代谢和动力学受损，已成为细胞衰老的一个标志。另一方面，有研究表明，线粒体稳态的破坏会诱导细胞衰老。本综述旨在概述线粒体内部的稳态机制，并全面深入了解细胞衰老与线粒体功能障碍之间的相互作用。
