来自柳珊瑚（Ellisellidae）的新 11,20-环氧布里亚烷。

New 11,20-Epoxybriaranes from the Gorgonian Coral (Ellisellidae).

机构信息

Department of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.

National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.

出版信息

Molecules. 2019 Jul 7;24(13):2487. doi: 10.3390/molecules24132487.

DOI:10.3390/molecules24132487

PMID:31284657

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6659381/

Abstract

Two new 11,20-epoxybriaranes, fragilides P () and Q (), as well as two known analogues, robustolide F () and juncin Z (), were obtained from the gorgonian coral . The structures, including the absolute configurations of briaranes and , were elucidated by using spectroscopic methods and comparing the spectroscopic and rotation data with those of known related analogues. Briarane decreased the generation of superoxide anions by human neutrophils. The propionate group in is rarely found.

摘要

从柳珊瑚中分离得到两个新的 11,20-环氧倍半萜 Briaranes，即 fragilides P () 和 Q ()，以及两个已知类似物 robustolide F () 和 juncin Z ()。通过光谱方法并比较与已知相关类似物的光谱和旋转数据，阐明了 Briaranes 和的结构，包括它们的绝对构型。Briarane 可减少人嗜中性粒细胞中超氧阴离子的产生。在中，丙酸酯基是很少见的。