掘海绵内酯U-Z，源自掘海绵软珊瑚的新型刺柏烷二萜类化合物。

Excavatolides U-Z, new briarane diterpenes from the gorgonian briareum excavatum.

作者信息

Sheu JH, Sung PJ, Su JH, Wang GH, Duh CY, Shen YC, Chiang MY, Chen IT

机构信息

Department of Marine Resources and Department of Chemistry, National Sun Yat-Sen University, Kaohsiung, Taiwan 804, Republic of China.

出版信息

J Nat Prod. 1999 Oct;62(10):1415-20. doi: 10.1021/np990302i.

DOI:10.1021/np990302i

PMID:10543904

Abstract

A recent study of the EtOAc extract of the gorgonian Briareum excavatum afforded six new diterpenes of the briarane skeleton, excavatolides U-Z (1-6). The structures and relative stereochemistry of metabolites 1-6 were assigned on the basis of NMR studies and chemical methods. The structure, including the relative configuration of excavatolide U (1), was further confirmed by a single-crystal X-ray analysis. Some of the excavatolides have displayed significant cytotoxicity toward P-388 and HT-29 tumor cells.

摘要

最近一项对柳珊瑚Briareum excavatum乙酸乙酯提取物的研究得到了六种新的具有刺囊烷骨架的二萜类化合物，即掘珊瑚内酯U-Z（1-6）。代谢产物1-6的结构和相对立体化学是根据核磁共振研究和化学方法确定的。掘珊瑚内酯U（1）的结构，包括其相对构型，通过单晶X射线分析得到了进一步证实。一些掘珊瑚内酯对P-388和HT-29肿瘤细胞显示出显著的细胞毒性。