Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
Mar Drugs. 2019 Sep 14;17(9):534. doi: 10.3390/md17090534.
Three new 8-hydroxybriaranes-fragilides R-T (-) were obtained from a sea whip gorgonian coral . The structures of briaranes - were elucidated by using spectroscopic methods, including 1D (H and C NMR), 2D (COSY, HSQC, HMBC, and NOESY experiments) NMR studies, and (+)-HRESIMS. Fragilides S and T ( and ) are the only briaranes known to possess 8α-hydroxy and 17β-methyl groups, respectively. Briarane exerted an inhibition effect on iNOS release from RAW264.7; a macrophage cell line that originated from a mouse monocyte macrophage, stimulated with lipopolysaccharides.
从一种海鞭柳珊瑚中获得了三种新的 8-羟基布里亚烷- fragilides R-T(-)。通过使用包括 1D（H 和 C NMR）、2D（COSY、HSQC、HMBC 和 NOESY 实验）NMR 研究和（+）-HRESIMS 在内的光谱方法阐明了 briaranes-的结构。fragilides S 和 T（和）是唯一已知具有 8α-羟基和 17β-甲基的 briaranes。布里亚烷对脂多糖刺激的 RAW264.7（一种源自小鼠单核巨噬细胞的巨噬细胞系）中 iNOS 释放有抑制作用。
