Science Division, New York University Abu Dhabi, Saadiyat Island, Abu Dhabi, United Arab Emirates.
Chem Commun (Camb). 2019 Jul 23;55(60):8876-8879. doi: 10.1039/c9cc02214g.
Here we report template-free synthesis of imine-linked calix[4]arene hollow nanocapsules and their utility in the effective delivery of a poorly soluble cancer drug into tumor cells. These stimuli-responsive nanocapsules show high drug loading and release which resulted in a 40-fold higher cytotoxicity for breast cancer cell line over normal cells.
在这里，我们报告了无模板合成亚胺键连接的杯[4]芳烃中空纳米胶囊及其在有效递送入肿瘤细胞的一种难溶性抗癌药物中的应用。这些对刺激响应的纳米胶囊表现出高药物负载和释放，从而使乳腺癌细胞系的细胞毒性比正常细胞高出 40 倍。
