Subbarao B, Ahmed A, Paul W E, Scher I, Lieberman R, Mosier D E
J Immunol. 1979 Jun;122(6):2279-85.
Anti-Lyb-5.1 serum contains antibodies against two different B cell surface antigenic determinants, Lyb-5.1 and Lyb-7.1, which are defined in cytotoxicity and functional tests, respectively. The antibody against Lyb-7.1 is identified by its ability to specifically inhibit in vitro primary antibody responses to TNP-Ficoll. Anti-Lyb-5.1 serum can be made monospecific for anti-Lyb-7.1 activity by absorption with spleen cells from AL/N mice which have been typed as Lyb-5.1+, Lyb-7.1-. Lyb-5.1 and Lyb-7.1 are each under control of one or one set of closely linked genes. The loci specifying Lyb-5.1 and Lby-7.1 are not linked to each other nor to M1s and H-2 loci. However, the gene controlling the expression of Lyb-7.1 is linked to the genes coding for the constant region of immunoglobulin heavy chains.
抗Lyb-5.1血清含有针对两种不同B细胞表面抗原决定簇Lyb-5.1和Lyb-7.1的抗体，这两种抗原决定簇分别在细胞毒性试验和功能试验中得以界定。抗Lyb-7.1抗体通过其特异性抑制体外针对TNP-菲柯尔的初次抗体反应的能力得以识别。通过用已被鉴定为Lyb-5.1阳性、Lyb-7.1阴性的AL/N小鼠的脾细胞进行吸收处理，抗Lyb-5.1血清可以针对抗Lyb-7.1活性制备成单特异性血清。Lyb-5.1和Lyb-7.1各自受一个或一组紧密连锁基因的控制。指定Lyb-5.1和Lyb-7.1的基因座彼此不连锁，也不与M1s和H-2基因座连锁。然而，控制Lyb-7.1表达的基因与编码免疫球蛋白重链恒定区的基因连锁。
