胸腺在指导B淋巴细胞亚群发育中的作用。
Role of the thymus in directing the development of a subset of B lymphocytes.
作者信息
Mond J J, Scher I, Cossman J, Kessler S, Mongini P K, Hansen C, Finkelman F D, Paul W E
出版信息
J Exp Med. 1982 Mar 1;155(3):924-36. doi: 10.1084/jem.155.3.924.
In an effort to evaluate the role of the thymus in influencing the development of Lyb-5- B lymphocytes, mice expressing both the xid and nu gene defects were studied. Mice expressing either of these defects respond to both trinitrophenylated Brucellus abortus and lipopolysaccharide; whereas mice with the combined defect show markedly suppressed responses. The other abnormalities included: (a) greater than 80 percent diminution of serum Ig levels; (b) significant increase in the number of sIgM+ sIgD- B lymphocytes; (c) reduced expression of IgD on sIgD+ cells; and (d) a strikingly abnormal histology of their lymphoid tissue. Because nu/nu mice that do not express the xid defect appear relatively normal, it would suggest that the development of Lyb-5- B lymphocytes require a thymic influence for normal maturation, whereas, Lyb-5+ B lymphocytes are relatively independent of such influences.
为了评估胸腺在影响Lyb-5⁻ B淋巴细胞发育中的作用，对同时表达xid和nu基因缺陷的小鼠进行了研究。表达这两种缺陷之一的小鼠对三硝基苯化流产布鲁氏菌和脂多糖均有反应；而具有联合缺陷的小鼠则表现出明显的反应抑制。其他异常包括：（a）血清Ig水平降低超过80%；（b）sIgM⁺ sIgD⁻ B淋巴细胞数量显著增加；（c）sIgD⁺细胞上IgD表达减少；以及（d）其淋巴组织的组织学明显异常。由于不表达xid缺陷的nu/nu小鼠看起来相对正常，这表明Lyb-5⁻ B淋巴细胞的发育需要胸腺影响以实现正常成熟，而Lyb-5⁺ B淋巴细胞相对独立于这种影响。
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