tiRNAs：一类新的小非编码 RNA，有助于细胞应对应激，并在癌症进展中发挥作用。
tiRNAs: A novel class of small noncoding RNAs that helps cells respond to stressors and plays roles in cancer progression.
机构信息
Division of Gastroenterology and Hepatology, Shanghai Institute of Digestive Disease, State Key Laboratory for Oncogenes and Related Genes, Key Laboratory of Gastroenterology & Hepatology, Ministry of Health, Ren-Ji Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China.
Institute of Digestive Disease and Department of Medicine and Therapeutics, State Key Laboratory of Digestive Disease, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
出版信息
J Cell Physiol. 2020 Feb;235(2):683-690. doi: 10.1002/jcp.29057. Epub 2019 Jul 8.
tRNA-derived stress-induced RNAs (tiRNAs), important components of tRNA-derived fragments, are gaining popularity for their functions as small noncoding RNAs involved in cancer progression. Under cellular stress, tiRNAs are generated when mature tRNA is specifically cleaved by angiogenin and suggested to act as transducers or effectors involved in cellular stress responses. tiRNAs facilitate cells to respond to stresses mainly via reprogramming translation, inhibiting apoptosis, degrading mRNA, and generating stress granules. This review introduces the cellular biogenesis, molecular mechanisms, and biological roles of tiRNAs in stress response and disease regulation. A better understanding of their roles in regulating cancer may provide novel biomarkers or therapeutic targets for diagnosis and treatment.
tRNA 衍生的应激诱导 RNA（tiRNA）是 tRNA 衍生片段的重要组成部分，作为参与癌症进展的小非编码 RNA，其功能日益受到关注。在细胞应激下，成熟 tRNA 被血管生成素特异性切割产生 tiRNA，并被认为作为细胞应激反应中的转导子或效应子发挥作用。tiRNA 通过重编程翻译、抑制细胞凋亡、降解 mRNA 和生成应激颗粒来促进细胞对应激的响应。本文介绍了 tiRNA 在应激反应和疾病调控中的细胞生物发生、分子机制和生物学作用。更好地了解它们在调控癌症中的作用可能为诊断和治疗提供新的生物标志物或治疗靶点。
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