Harkness R A, Purkiss P, Duffy S, Chalmers R A, Jones M
Division of Inherited Metabolic Diseases, MRC Clinical Research Centre, Middlesex, UK.
J Inherit Metab Dis. 1988;11(1):103-13. doi: 10.1007/BF01800060.
Concentrations of amino and organic acids, phosphate, sulphate, gluconic acid and gluconolactone were measured in amniotic fluid samples which contained either normal or raised hypoxanthine concentrations. In this way, the effect of mild fetal ATP depletion could be determined. The effects of this mild asphyxia were to raise concentrations of phenylalanine, tyrosine, lysine, glycine, phosphate, sulphate, gluconic acid and glucono-1,5-lactone. However, concentrations of a variety of other metabolites were unchanged; thus no diagnostic confusion should arise with organic acidurias in mild asphyxia in contrast to the biochemical mimickry produced by severe asphyxia. Since clinically normal parturition can produce changes in amniotic fluid, urine from newborn or cord blood may not reflect the metabolic balance in utero.
在含有正常或升高的次黄嘌呤浓度的羊水样本中，测量了氨基酸、有机酸、磷酸盐、硫酸盐、葡萄糖酸和葡萄糖酸内酯的浓度。通过这种方式，可以确定轻度胎儿ATP耗竭的影响。这种轻度窒息的影响是提高苯丙氨酸、酪氨酸、赖氨酸、甘氨酸、磷酸盐、硫酸盐、葡萄糖酸和葡萄糖-1,5-内酯的浓度。然而，其他多种代谢物的浓度没有变化；因此，与严重窒息产生的生化模拟不同，轻度窒息时有机酸尿症不应引起诊断混淆。由于临床正常分娩可导致羊水变化，新生儿尿液或脐血可能无法反映子宫内的代谢平衡。
