Institute of Biotechnology , Technical University of Berlin , Ackerstraße 76 , 13355 Berlin , Germany.
J Nat Prod. 2019 Jul 26;82(7):2038-2053. doi: 10.1021/acs.jnatprod.9b00110. Epub 2019 Jul 9.
is widely underappreciated for its inherent biosynthetic potential. This report comprehensively summarizes the known bioactive secondary metabolites from and highlights potential applications as plant pathogen control agents, drugs, and biosurfactants. is well known for the production of cyclic lipopeptides exhibiting strong surfactant and antimicrobial activities, such as surfactins, iturins, and fengycins. Several polyketide-derived macrolides as well as nonribosomal peptides, dihydroisocoumarins, and linear lipopeptides with antimicrobial properties have been reported, demonstrating the biosynthetic arsenal of this bacterium. Promising efforts toward the application of strains and their natural products in areas of agriculture and medicine are underway. However, industrial-scale availability of these compounds is currently limited by low fermentation yields and challenging accessibility via synthesis, necessitating the development of genetically engineered strains and optimized cultivation processes. We hope that this review will attract renewed interest in this often-overlooked bacterium and its impressive biosynthetic skill set.
其内在的生物合成潜力尚未得到充分重视。本报告全面总结了 中已知的生物活性次生代谢产物，并强调了其作为植物病原体防治剂、药物和生物表面活性剂的潜在应用。 以产生具有强表面活性剂和抗菌活性的环状脂肽而闻名，如表面活性剂、伊曲菌素和丰加菌素。已经报道了几种聚酮衍生的大环内酯以及非核糖体肽、二氢异香豆素和具有抗菌特性的线性脂肽，展示了该细菌的生物合成武器库。正在进行利用 菌株及其天然产物在农业和医学领域的应用的有希望的努力。然而，这些化合物的工业规模可用性目前受到发酵产量低和通过合成获得的挑战性的限制，需要开发基因工程菌株和优化的培养工艺。我们希望本综述将重新引起人们对这种经常被忽视的细菌及其令人印象深刻的生物合成技能的兴趣。
