Inokuchi A, Boran T V, Kimmelman C P, Snow J B
Department of Otorhinolaryngology and Human Communication, University of Pennsylvania School of Medicine, Philadelphia 19104.
Otolaryngol Head Neck Surg. 1988 Feb;98(2):116-20. doi: 10.1177/019459988809800204.
The effects of electrical stimulation of the olfactory bulb and the locus ceruleus on olfactory tubercle neurons were examined in rat models. Ipsilateral stimulation of the olfactory bulb produced excitation in 31% of olfactory tubercle neurons tested and inhibition in 17%. Twenty-two percent of the olfactory tubercle neurons were excited, whereas 9% were inhibited by ipsilateral stimulation of the locus ceruleus. Contralateral stimulation of the locus ceruleus produced similar responses in the same neuron entities. A negative-positive evoked potential was recorded in the olfactory tubercle after ipsilateral and contralateral stimulation of the locus ceruleus. Thirty-three percent of the olfactory tubercle neurons that responded orthodromically or antidromically to stimulation of the olfactory bulb were excited by ipsilateral stimulation of the locus ceruleus. In contrast, only 10% responded with excitation to ipsilateral stimulation of the locus ceruleus among the olfactory tubercle neurons that were unresponsive to stimulation of the olfactory bulb. These findings suggest that olfactory tubercle neurons that receive input from or sending output to the olfactory bulb are influenced by the noradrenergic system of the locus ceruleus. A possible role of the olfactory tubercle in olfactory transduction will also be discussed.
在大鼠模型中研究了电刺激嗅球和蓝斑对嗅结节神经元的影响。同侧刺激嗅球时，在所测试的嗅结节神经元中有31%产生兴奋，17%产生抑制。当同侧刺激蓝斑时，22%的嗅结节神经元被兴奋，而9%被抑制。当对蓝斑进行对侧刺激时，在相同的神经元群体中产生了类似的反应。在同侧和对侧刺激蓝斑后部，在嗅结节处记录到一个正负诱发电位。对刺激嗅球有顺向或逆向反应的嗅结节神经元中，33%被同侧刺激蓝斑兴奋。相比之下，在对刺激嗅球无反应的嗅结节神经元中，只有10%被同侧刺激蓝斑兴奋。这些发现表明，从嗅球接收输入或向嗅球发送输出的嗅结节神经元受蓝斑去甲肾上腺素能系统的影响。还将讨论嗅结节在嗅觉转导中的可能作用。
