Department of Clinical Sciences Malmö, Clinical and Molecular Osteoporosis Research Unit, Lund University, Malmö, Sweden.
Department of Orthopedics, Skåne University Hospital, Malmö, Sweden.
J Clin Endocrinol Metab. 2019 Dec 1;104(12):6139-6147. doi: 10.1210/jc.2019-00573.
Vitamin D (25OHD) is involved in many physiological functions that decline with age, contributing to frailty and increased risk for negative health outcomes. Whether 25OHD is a long-term risk marker for frailty over a longer time and whether it is consistent with advancing age is unclear.
To investigate the association between 25OHD and frailty in older women followed for 10 years.
Prospective, population-based, cohort study in Malmö, Sweden.
Community-dwelling women, age 75 years (N = 1044) with reassessments at ages 80 (n = 715) and 85 (n = 382) years.
Frailty was quantified using a 10-variable frailty index. Women were categorized as 25OHD insufficient (<50 nmol/L) or sufficient (≥50 nmol/L).
At ages 75 and 80 years, women with insufficient 25OHD were frailer than women with sufficient 25OHD (0.23 vs 0.18, P < 0.001; and 0.32 vs 0.25, P = 0.001, respectively). At age 80 years, 25OHD insufficiency was associated with subsequent frailty 5 years later (0.41 vs 0.32; P = 0.011). Accelerated progression of frailty was not associated with lower 25OHD levels, and 25OHD level >75 nmol/L was not additionally beneficial with regard to frailty. No association between 25OHD and frailty was observed at age 85 years. Within the frailty index, variables associated with 25OHD were related to muscle strength and function.
In this study, 25OHD insufficiency was associated with increased frailty in all but the oldest old. This study supports the value of maintaining sufficient 25OHD levels for healthy aging.
维生素 D（25OHD）参与许多随年龄增长而衰退的生理功能，导致虚弱和健康不良后果的风险增加。25OHD 是否是较长时间内虚弱的长期风险标志物，以及它是否与年龄增长一致尚不清楚。
调查 10 年内随访的老年女性中 25OHD 与虚弱之间的关系。
瑞典马尔默的前瞻性、基于人群的队列研究。
75 岁的社区居住女性（N=1044），在 80 岁（n=715）和 85 岁（n=382）时进行重新评估。
使用 10 变量虚弱指数来量化虚弱。女性分为 25OHD 不足（<50 nmol/L）或充足（≥50 nmol/L）。
在 75 岁和 80 岁时，25OHD 不足的女性比 25OHD 充足的女性更虚弱（0.23 与 0.18，P<0.001；0.32 与 0.25，P=0.001）。在 80 岁时，25OHD 不足与 5 年后的虚弱相关（0.41 与 0.32；P=0.011）。虚弱的加速进展与较低的 25OHD 水平无关，25OHD 水平>75 nmol/L 对虚弱也没有额外的益处。在 85 岁时，25OHD 与虚弱之间没有关联。在虚弱指数中，与 25OHD 相关的变量与肌肉力量和功能有关。
在这项研究中，25OHD 不足与所有年龄组但最年长的老年人虚弱有关。这项研究支持维持足够的 25OHD 水平以促进健康衰老的价值。
