Follette Christelle M, Giuffrida Michelle A, Balsa Ingrid M, Culp William T N, Mayhew Philipp D, Oblak Michelle L, Singh Ameet, Steffey Michele A
Department of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, California.
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada.
Vet Surg. 2020 Jan;49(1):61-69. doi: 10.1111/vsu.13279. Epub 2019 Jul 9.
To evaluate reporting of surgical complications and other adverse events in clinical research articles describing soft tissue and oncologic surgery in dogs and cats.
Systematic literature review.
English-language articles describing soft tissue and oncologic surgeries in client-owned dogs and cats published in peer-reviewed journals from 2013 to 2016.
CAB, AGRICOLA, and MEDLINE databases were searched for eligible articles. Article characteristics relevant to complications were abstracted and summarized, including reported events, definitions, criteria used to classify events according to severity and time frame, and relevant citations.
One hundred fifty-one articles involving 10 522 animals were included. Canine retrospective case series of dogs predominated. Ninety-two percent of articles mentioned complications in study results, but only 7.3% defined the term complication. Articles commonly described complications according to time frame and severity, but terminology and classification criteria were highly variable, conflicting between studies, or not provided. Most (58%) reported complications could have been graded with a published veterinary adverse event classification scheme, although common intraoperative complications were notable exceptions.
Definitions and criteria used to classify and report soft tissue and oncologic surgical complications are often absent, incomplete, or contradictory among studies.
Lack of consistent terminology contributes to inadequate communication of important information about surgical complications. Standardization of terminology and consistency in severity scoring will improve comparative evaluation of clinical research results.
评估在描述犬猫软组织和肿瘤手术的临床研究文章中手术并发症及其他不良事件的报告情况。
系统文献综述。
2013年至2016年在同行评审期刊上发表的描述宠物犬猫软组织和肿瘤手术的英文文章。
检索CAB、AGRICOLA和MEDLINE数据库以获取符合条件的文章。提取并总结与并发症相关的文章特征，包括报告的事件、定义、根据严重程度和时间框架对事件进行分类的标准以及相关引用。
纳入了涉及10522只动物的151篇文章。以犬的回顾性病例系列为主。92%的文章在研究结果中提及了并发症，但只有7.3%对“并发症”一词进行了定义。文章通常根据时间框架和严重程度描述并发症，但术语和分类标准差异很大，研究之间相互矛盾或未提供。大多数（58%）报告的并发症本可以用已发表的兽医不良事件分类方案进行分级，不过常见的术中并发症是明显的例外。
研究中用于分类和报告软组织及肿瘤手术并发症的定义和标准往往缺失、不完整或相互矛盾。
缺乏一致的术语导致关于手术并发症的重要信息沟通不足。术语标准化和严重程度评分的一致性将改善临床研究结果的比较评估。
