Meek Richard William, Vyas Hrushi, Piddock Laura Jane Violet
Institute of Microbiology and Infection, University Of Birmingham, Birmingham, United Kingdom.
PLoS Biol. 2015 Oct 7;13(10):e1002266. doi: 10.1371/journal.pbio.1002266. eCollection 2015 Oct.
The global crisis of antibiotic resistance has reached a point where, if action is not taken, human medicine will enter a postantibiotic world and simple injuries could once again be life threatening. New antibiotics are needed urgently, but better use of existing agents is just as important. More appropriate use of antibiotics in medicine is vital, but the extensive use of antibiotics outside medical settings is often overlooked. Antibiotics are commonly used in animal husbandry, bee-keeping, fish farming and other forms of aquaculture, ethanol production, horticulture, antifouling paints, food preservation, and domestically. This provides multiple opportunities for the selection and spread of antibiotic-resistant bacteria. Given the current crisis, it is vital that the nonmedical use of antibiotics is critically examined and that any nonessential use halted.
如果不采取行动,人类医学将进入后抗生素时代,简单的伤口可能再次危及生命。迫切需要新的抗生素,但更好地使用现有药物同样重要。在医学中更合理地使用抗生素至关重要,但在医疗环境之外广泛使用抗生素的情况却常常被忽视。抗生素常用于畜牧业、养蜂业、养鱼业及其他形式的水产养殖、乙醇生产、园艺、防污涂料、食品保鲜以及家庭用途。这为抗生素耐药菌的选择和传播提供了多重机会。鉴于当前的危机,至关重要的是要严格审查抗生素的非医疗用途,并停止任何不必要的使用。