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间充质基质细胞疗法治疗受损视网膜神经节细胞，闪光的都是金子吗？

Mesenchymal stromal cell therapy for damaged retinal ganglion cells, is gold all that glitters?

作者信息

Lucas-Ruiz Fernando, Galindo-Romero Caridad, García-Bernal David, Norte-Muñoz María, Rodríguez-Ramírez Kristy T, Salinas-Navarro Manuel, Millán-Rivero Jose E, Vidal-Sanz Manuel, Agudo-Barriuso Marta

机构信息

Grupo de Oftalmología Experimental, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca); Department of Talmología, Universidad de Murcia, Murcia, Spain.

Unidad de Terapia Celular y Trasplante Hematopoyético, Instituto Murciano de Investigación Biosanitaria Virgen de la Arrixaca (IMIB-Arrixaca); Department of Medicina Interna, Universidad de Murcia, Murcia, Spain.

出版信息

Neural Regen Res. 2019 Nov;14(11):1851-1857. doi: 10.4103/1673-5374.259601.

DOI:10.4103/1673-5374.259601
PMID:31290434
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6676874/
Abstract

Mesenchymal stromal cells are an excellent source of stem cells because they are isolated from adult tissues or perinatal derivatives, avoiding the ethical concerns that encumber embryonic stem cells. In preclinical models, it has been shown that mesenchymal stromal cells have neuroprotective and immunomodulatory properties, both of which are ideal for central nervous system treatment and repair. Here we will review the current literature on mesenchymal stromal cells, focusing on bone marrow mesenchymal stromal cells, adipose-derived mesenchymal stromal cells and mesenchymal stromal cells from the umbilical cord stroma, i.e., Wharton's jelly mesenchymal stromal cells. Finally, we will discuss the use of these cells to alleviate retinal ganglion cell degeneration following axonal trauma.

摘要

间充质基质细胞是一种优秀的干细胞来源，因为它们是从成人组织或围产期衍生物中分离出来的，避免了困扰胚胎干细胞的伦理问题。在临床前模型中，已表明间充质基质细胞具有神经保护和免疫调节特性，这两者对于中枢神经系统的治疗和修复都是理想的。在这里，我们将回顾关于间充质基质细胞的当前文献，重点关注骨髓间充质基质细胞、脂肪来源的间充质基质细胞和脐带基质间充质基质细胞，即华通氏胶间充质基质细胞。最后，我们将讨论使用这些细胞来减轻轴突损伤后视网膜神经节细胞的退化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3677/6676874/b1432860deed/NRR-14-1851-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3677/6676874/b1432860deed/NRR-14-1851-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3677/6676874/b1432860deed/NRR-14-1851-g001.jpg

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本文引用的文献

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Differentiation of human mesenchymal stem cells (MSC) to dopaminergic neurons: A comparison between Wharton's Jelly and olfactory mucosa as sources of MSCs.人骨髓间充质干细胞（MSC）向多巴胺能神经元的分化：以牙髓和嗅黏膜为MSC 来源的比较。
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Adipose Stem Cell Translational Applications: From Bench-to-Bedside.脂肪干细胞转化应用：从基础到临床。
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Human Wharton's jelly mesenchymal stem cells protect axotomized rat retinal ganglion cells via secretion of anti-inflammatory and neurotrophic factors.
脉络膜下巩膜球体间质干细胞植入治疗色素性视网膜炎：6 个月随访的临床结果。
Stem Cell Res Ther. 2023 Sep 13;14(1):252. doi: 10.1186/s13287-023-03489-z.
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Aldose reductase inhibition decelerates optic nerve degeneration by alleviating retinal microglia activation.醛糖还原酶抑制通过减轻视网膜小胶质细胞的激活来延缓视神经变性。
Sci Rep. 2023 Apr 5;13(1):5592. doi: 10.1038/s41598-023-32702-5.
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Bone marrow-derived mononuclear stem cells in the treatment of retinal degenerations.骨髓来源的单个核干细胞在视网膜变性治疗中的应用
Neural Regen Res. 2022 Sep;17(9):1937-1944. doi: 10.4103/1673-5374.335692.
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Biology (Basel). 2021 Nov 15;10(11):1181. doi: 10.3390/biology10111181.
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Front Cell Dev Biol. 2021 Nov 4;9:772223. doi: 10.3389/fcell.2021.772223. eCollection 2021.
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