Department of Chemistry, Virginia Commonwealth University, 1001 West Main Street, P. O. Box 842006, Richmond, VA 23284, USA.
School of Mathematics & Natural Sciences, Chemistry & Biochemistry, 118 College Drive #5043, Hattiesburg, MS 39406, USA.
Chem Commun (Camb). 2019 Aug 7;55(61):8959-8962. doi: 10.1039/c8cc10192b. Epub 2019 Jul 10.
Hydrocarbon stapled peptides are promising therapeutics for inhibition of intracellular protein-protein interactions. Here we develop a new high-throughput strategy for hydrocarbon stapled peptide discovery based on mRNA display of peptides containing α-methyl cysteine and cyclized with m-dibromoxylene. We focus on development of a peptide binder to the HPV16 E2 protein.
碳氢化合物订书肽是抑制细胞内蛋白质-蛋白质相互作用的有前途的治疗方法。在这里，我们开发了一种基于含有α-甲基半胱氨酸的肽的 mRNA 展示和与 m-二溴对二甲苯环化的新型高通量碳氢化合物订书肽发现策略。我们专注于开发针对 HPV16 E2 蛋白的肽结合物。
