Department of Microbiology, Harbin Medical University, Xuefu Road, Nangang District, Harbin, China.
Wu Lien-Teh Institute, Harbin Medical University, Xuefu Road, Nangang District, Harbin, China.
Database (Oxford). 2019 Jan 1;2019. doi: 10.1093/database/baz074.
The emergence and spread of drug-resistant Mycobacterium tuberculosis is of global concern. To improve the understanding of drug resistance in Mycobacteria, numerous studies have been performed to discover diagnostic markers and genetic determinants associated with resistance to anti-tuberculosis drug. However, the related information is scattered in a massive body of literature, which is inconvenient for researchers to investigate the molecular mechanism of drug resistance. Therefore, we manually collected 1707 curated associations between 73 compounds and 132 molecules (including coding genes and non-coding RNAs) in 6 mycobacterial species from 465 studies. The experimental details of molecular epidemiology and mechanism exploration research were also summarized and recorded in our work. In addition, multidrug resistance and extensively drug resistance molecules were also extracted to interpret the molecular mechanisms that are responsible for cross resistance among anti-tuberculosis drugs. Finally, we constructed an omnibus repository named MycoResistance, a user friendly interface to conveniently browse, search and download all related entries. We hope that this elaborate database will serve as a beneficial resource for mechanism explanations, precise diagnosis and effective treatment of drug-resistant mycobacterial strains.
耐药结核分枝杆菌的出现和传播引起了全球关注。为了提高对分枝杆菌耐药性的认识，已经进行了大量研究来发现与抗结核药物耐药性相关的诊断标志物和遗传决定因素。然而，相关信息分散在大量文献中，这使得研究人员难以研究耐药性的分子机制。因此，我们从 465 项研究中手动收集了 6 种分枝杆菌中 73 种化合物和 132 种分子（包括编码基因和非编码 RNA）之间的 1707 个经过精心整理的关联。我们的工作还总结和记录了分子流行病学和机制探索研究的实验细节。此外，还提取了耐多药和广泛耐药的分子，以解释导致抗结核药物交叉耐药的分子机制。最后，我们构建了一个名为 MycoResistance 的综合存储库，这是一个用户友好的界面，可以方便地浏览、搜索和下载所有相关条目。我们希望这个精心制作的数据库将成为解释耐药性分枝杆菌菌株机制、精确诊断和有效治疗的有益资源。
