Medical School, Shandong University of Traditional Chinese Medicine, Jinan, 250355, China.
Mol Cell Biochem. 2024 Nov;479(11):2921-2953. doi: 10.1007/s11010-023-04919-5. Epub 2024 Feb 2.
Non-coding RNAs (ncRNAs) have key roles in the etiology of many illnesses, including heart failure, myocardial infarction, stroke, and in physiological processes like angiogenesis. In transcriptional regulatory circuits that control heart growth, signaling, and stress response, as well as remodeling in cardiac disease, ncRNAs have become important players. Studies on ncRNAs and cardiovascular disease have made great progress recently. Here, we go through the functions of non-coding RNAs (ncRNAs) like circular RNAs (circRNAs), and microRNAs (miRNAs) as well as long non-coding RNAs (lncRNAs) in modulating cardiovascular disorders.
非编码 RNA(ncRNA)在许多疾病的发病机制中起着关键作用,包括心力衰竭、心肌梗死、中风,以及血管生成等生理过程。在控制心脏生长、信号转导和应激反应的转录调控回路中,以及在心脏疾病的重塑中,ncRNA 已成为重要的参与者。最近,ncRNA 与心血管疾病的研究取得了重大进展。在这里,我们探讨了环状 RNA(circRNA)、微小 RNA(miRNA)和长非编码 RNA(lncRNA)等非编码 RNA(ncRNA)在调节心血管疾病中的作用。