非编码 RNA：健康与疾病的沉默调控者。
Non-coding RNAs: the silent regulators of health and diseases.
机构信息
School of Medical Science and Technology, Indian Institute of Technology Kharagpur, Paschim Medinipur, Kharagpur, 721302, India.
出版信息
Mol Biol Rep. 2022 Jul;49(7):6971-6973. doi: 10.1007/s11033-022-07464-4. Epub 2022 Apr 25.
Non-coding RNAs (ncRNAs) like miRNAs, siRNA, lncRNAs, circRNAs, piRNAs, snoRNAs, snRNAs etc. form a collective group of RNAs that is instrumental to the various functions of the genome. With the advent of cutting-edge molecular biology tools and techniques, scientists have unearthed several mechanisms through which these ncRNAs act. Although our understanding may still be limited, yet scientists have been able to establish ncRNAs as major regulators of genetic inter-plays that dictate various pathophysiological conditions. This special issue of Molecular Biology Reports features a collection of research and review articles on ncRNAs and their involvement in different pathophysiological conditions that include different types of cancers. It is expected that this special issue will motivate researchers in the field to delve deeper into the world of ncRNAs and attempt to develop new diagnostic and therapeutic interventions for challenging clinical conditions.
非编码 RNA（ncRNA），如 miRNA、siRNA、lncRNA、circRNA、piRNA、snoRNA、snRNA 等，形成了一个 RNA 集体，对基因组的各种功能至关重要。随着前沿分子生物学工具和技术的出现，科学家们已经发现了这些 ncRNA 发挥作用的几种机制。尽管我们的理解可能仍然有限，但科学家们已经能够确定 ncRNA 是遗传相互作用的主要调节剂，这些相互作用决定了各种病理生理状况。本期《分子生物学报告》特刊收录了一系列关于 ncRNA 及其在不同病理生理条件下的研究和综述文章，包括不同类型的癌症。预计本期特刊将激励该领域的研究人员更深入地研究 ncRNA 领域，并尝试为具有挑战性的临床状况开发新的诊断和治疗干预措施。
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