Goldreich Jennifer E, Franklin-Guild Rebecca J, Ledbetter Eric C
Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, Ithaca, NY.
Vet Ophthalmol. 2020 Jan;23(1):90-96. doi: 10.1111/vop.12693. Epub 2019 Jul 10.
To describe clinical characteristics, bacterial isolates, and in vitro antimicrobial susceptibility patterns for cats with bacterial keratitis.
Eighty one cats with bacterial keratitis.
Medical records of cats with a clinical diagnosis of bacterial keratitis, confirmed by corneal culture, were reviewed from June 2004 to July 2017. Animal signalment, bacterial isolates, aerobic bacteria in vitro antimicrobial susceptibility test results, and pertinent clinical features were recorded. Percentages of susceptible aerobic bacterial isolates were statistically compared among selected antimicrobials.
There were 102 aerobic bacterial isolates recovered from corneal samples of the 81 cats presented with bacterial keratitis. The most frequent bacteria isolated were Staphylococcus species, which constituted 55% (56/102) of total isolates. All aerobic bacterial isolates grouped together had the highest percentage of susceptibility to ofloxacin (100%), ciprofloxacin (94%), chloramphenicol (93%), doxycycline (92%), ticarcillin (90%), gentamicin (89%), moxifloxacin (89%), tobramycin (86%), neomycin (85%), amikacin (84%), and cefazolin (84%). The same isolates had the lowest percentage of susceptibility to polymyxin B (2%), bacitracin (15%), and clindamycin (31%). When analyzed separately, the isolated Staphylococcus species had the highest percentage of susceptibility to ofloxacin (100%), tobramycin (93%), and neomycin (85%) and the lowest percentage of susceptibility to polymyxin B (3%) and bacitracin (13%).
Members of the Staphylococcus genus were the most frequent bacteria isolated from cases of feline bacterial keratitis. On the basis of in vitro susceptibility testing and mechanism of action, ofloxacin, ciprofloxacin, ticarcillin, gentamicin, or moxifloxacin are recommended for initial antimicrobial therapy of suspected bacterial keratitis in cats.
描述猫细菌性角膜炎的临床特征、分离出的细菌及体外抗菌药敏模式。
81只患有细菌性角膜炎的猫。
回顾2004年6月至2017年7月临床诊断为细菌性角膜炎且经角膜培养确诊的猫的病历。记录动物的特征、分离出的细菌、需氧菌体外抗菌药敏试验结果及相关临床特征。对所选抗菌药物中敏感需氧菌分离株的百分比进行统计学比较。
从81只患有细菌性角膜炎的猫的角膜样本中分离出102株需氧菌。分离出的最常见细菌是葡萄球菌属，占分离株总数的55%（56/102）。所有聚集在一起的需氧菌分离株对氧氟沙星（100%）、环丙沙星（94%）、氯霉素（93%）、强力霉素（92%）、替卡西林（90%）、庆大霉素（89%）、莫西沙星（89%）、妥布霉素（86%）、新霉素（85%）、阿米卡星（84%）和头孢唑林（84%）的敏感率最高。相同的分离株对多粘菌素B（2%）、杆菌肽（15%）和克林霉素（31%）的敏感率最低。单独分析时，分离出的葡萄球菌属对氧氟沙星（100%）、妥布霉素（93%）和新霉素（85%）的敏感率最高，对多粘菌素B（3%）和杆菌肽（13%）的敏感率最低。
葡萄球菌属是猫细菌性角膜炎病例中最常分离出的细菌。基于体外药敏试验及作用机制，推荐氧氟沙星、环丙沙星、替卡西林、庆大霉素或莫西沙星用于猫疑似细菌性角膜炎的初始抗菌治疗。
