Muminovic Umihanic Mirnesa, Babic Romana, Kravic Nermina, Avdibegovic Esmina, Dzubur Kulenovic Alma, Agani Ferid, Jakovljevic Miro, Babic Dragan, Kucukalic Abdulah, Kucukalic Sabina, Sabic Dzananovic Emina, Bravo Mehmedbasic Alma, Goci Uka Aferdita, Haxhibeqiri Shpend, Hoxha Blerina, Haxhibeqiri Valdete, Aukst Margetic Branka, Jaksic Nenad, Cima Franc Ana, Rudan Dusko, Pavlović Marko, Feric Bojic Elma, Marjanovic Damir, Bozina Nada, Ziegler Christiane, Wolf Christiane, Warrings Bodo, Domschke Katharina, Deckert Jürgen, Sinanovic Osman
Community Health Center Zivinice, Alije Izetbegovica 17, 75270 Zivinice, Bosnia & Herzegovina,
Psychiatr Danub. 2019 Jun;31(2):235-240. doi: 10.24869/psyd.2019.235.
Previous research showed inconsistent results concerning a possible association between solute carrier family 6 member 3 (SLC6A3) gene polymorphisms and dopamine symptoms of posttraumatic stress disorder (PTSD). Several studies also indicate that the myelin basic protein (MBP) gene is of importance in the etiology of several psychiatric disorders. The aim of this study was to investigate the relation of distinct SLC6A3 and MBP gene polymorphisms with PTSD and whether SLC6A3 and MBP genotypes contribute to PTSD symptom severity.
The study included 719 individuals who had experienced war trauma in the South Eastern Europe (SEE). Genotypes of variable number tandem repeat (VNTR) polymorphism within the SLC6A3 gene were assessed in 696 participants, and the single nucleotide polymorphism (SNP) rs12458282 located within the MBP gene region was genotyped in a total of 703 subjects. The Mini International Neuropsychiatric Interview, the Clinical Administrated PTSD Scale (CAPS) and Brief Symptom Inventory (BSI), were used for data collection.
No significant differences concerning the investigated SLC6A3 and MBP polymorphisms was identifiable between PTSD and non PTSD participants. Also we could not detect significant influence of these distinct SLC6A3 and MBP alleles on the severity of PTSD symptoms (CAPS) or BSI scores. However, the results of MBP rs12458282 within the patients with lifetime PTSD may point to a possible correlation of the major allele (T) with elevated CAPS scores.
Our results do not support an association of the analysed SLC6A3 and MBP gene polymorphisms with PTSD in war traumatized individuals. We found that there is a possibility for a correlation of the T allele rs12458282 within the MBP gene with higher CAPS scores in lifetime PTSD patients which would need to be tested in a sample providing more statistical power.
先前的研究表明，溶质载体家族6成员3（SLC6A3）基因多态性与创伤后应激障碍（PTSD）的多巴胺症状之间可能存在关联，但结果并不一致。多项研究还表明，髓鞘碱性蛋白（MBP）基因在几种精神疾病的病因中具有重要作用。本研究的目的是调查不同的SLC6A3和MBP基因多态性与PTSD的关系，以及SLC6A3和MBP基因型是否对PTSD症状严重程度有影响。
该研究纳入了719名在东南欧（SEE）经历过战争创伤的个体。对696名参与者评估了SLC6A3基因内可变数目串联重复序列（VNTR）多态性的基因型，并对总共703名受试者进行了MBP基因区域内单核苷酸多态性（SNP）rs12458282的基因分型。使用迷你国际神经精神病学访谈、临床管理的PTSD量表（CAPS）和简明症状量表（BSI）进行数据收集。
在PTSD患者和非PTSD参与者之间，未发现所研究的SLC6A3和MBP多态性存在显著差异。我们也未检测到这些不同的SLC6A3和MBP等位基因对PTSD症状严重程度（CAPS）或BSI评分有显著影响。然而，终生患有PTSD的患者中MBP rs12458282的结果可能表明，主要等位基因（T）与CAPS评分升高之间可能存在相关性。
我们的结果不支持在经历战争创伤的个体中，所分析的SLC6A3和MBP基因多态性与PTSD存在关联。我们发现，MBP基因内的rs12458282 T等位基因与终生患有PTSD的患者较高的CAPS评分之间可能存在相关性，这需要在具有更大统计效力的样本中进行验证。
