Hoxha Blerina, Goçi Uka Afërdita, Agani Ferid, Haxhibeqiri Shpend, Haxhibeqiri Valdete, Sabic Dzananovic Emina, Kucukalic Sabina, Bravo Mehmedbasic Alma, Kucukalic Abdulah, Dzubur Kulenovic Alma, Feric Bojic Elma, Marjanovic Damir, Kravic Nermina, Avdibegovic Esmina, Muminovic Umihanić Mirnesa, Jaksic Nenad, Cima Franc Ana, Rudan Dusko, Jakovljevic Miro, Babic Romana, Pavlovic Marko, Babic Dragan, Aukst Margetic Branka, Bozina Nada, Sinanovic Osman, Ziegler Christiane, Warrings Bodo, Domschke Katharina, Deckert Jürgen, Wolf Christiane, Vyshka Gentian
Department of Psychiatry, University Clinical Centre of Kosovo, Prishtina, Kosovo,
Psychiatr Danub. 2019 Jun;31(2):263-268. doi: 10.24869/psyd.2019.263.
Posttraumatic stress disorder (PTSD) is a complex stress related disorder, that follows a severe traumatic experience, characterized with an intense sense of terror, fear, and helplessness. The aim of this study is to identify associations of genetic variations within candidate genes DRD2 and DRD4 with various PTSD related phenotypes. PTSD lifetime and PTSD current subjects were analyzed separately, each of them were analyzed in a Case/Control design, as well as regarding BSI and CAPS within cases only.
719 (487 male, 232 female) participants who had experienced war-related trauma between 1991 and 1999 in Bosnia and Hercegovina, Kosovo and Croatia were included in the study. Sociodemographic questionnaire, Clinician Administered PTSD Scale (CAPS) and the Brief Symptom Inventory (BSI) were used to collect clinical data.
The DRD2 rs1800497 variant and a variable number tandem repeat (VNTR) located in exon three of DRD4 were investigated for association with PTSD. In case control analyses we did not identify any significant associations. Within the PTSD current patients, we identified an association of DRD2 rs1800497 with BSI in the genotypic and the recessive model with the T allele as the risk allele.
Our findings suggest that rs1800497 of DRD2 gene is involved in pathogenesis of PTSD.
创伤后应激障碍（PTSD）是一种复杂的应激相关障碍，发生于严重创伤经历之后，其特征为强烈的恐惧、害怕和无助感。本研究的目的是确定候选基因DRD2和DRD4内的基因变异与各种PTSD相关表型之间的关联。对PTSD终身患者和PTSD现患患者分别进行分析，每组均采用病例/对照设计，且仅对病例组的简明症状量表（BSI）和临床医师用PTSD量表（CAPS）进行分析。
本研究纳入了719名（487名男性，232名女性）在1991年至1999年期间在波斯尼亚和黑塞哥维那、科索沃及克罗地亚经历过与战争相关创伤的参与者。使用社会人口学问卷、临床医师用PTSD量表（CAPS）和简明症状量表（BSI）收集临床数据。
研究了DRD2基因的rs1800497变异以及位于DRD4基因第三外显子的可变数目串联重复序列（VNTR）与PTSD的关联。在病例对照分析中，未发现任何显著关联。在PTSD现患患者中，我们发现DRD2基因的rs1800497在基因型和隐性模型中与BSI存在关联，以T等位基因为风险等位基因。
我们的研究结果表明，DRD2基因的rs1800497参与了PTSD的发病机制。
