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晚期胃癌所致难治性乳糜胸和淋巴水肿

Refractory Chylothorax and Lymphedema Caused by Advanced Gastric Cancer.

作者信息

Nagano Naoko, Suzuki Manabu, Tamura Kentaro, Kobayashi Sakurako, Kojima Yasushi, Naka Go, Iikura Motoyasu, Izumi Shinyu, Takeda Yuichiro, Sugiyama Haruhito

机构信息

Department of Respiratory Medicine, National Center for Global Health and Medicine, Japan.

Department of Gastroenterology, National Center for Global Health and Medicine, Japan.

出版信息

Intern Med. 2019 Nov 1;58(21):3143-3148. doi: 10.2169/internalmedicine.2351-18. Epub 2019 Jul 10.

DOI:10.2169/internalmedicine.2351-18
PMID:31292374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6875443/
Abstract

Chylothorax is the accumulation of lipid pleural effusion. Few reports have described chylothorax caused by gastric cancer. A 45-year-old woman presented with progressive lymphedema and bilateral chylothorax. Although repetitive thoracentesis was performed to relieve her dyspnea, swelling of her axillary lymph nodes became significant. Positron emission tomography/computed tomography demonstrated the accumulation of F-fluorodeoxyglucose in these nodes, and a lymph node biopsy showed signet ring cell carcinoma. The primary site was a 0-IIc type lesion in the gastric body that was only detected by upper gastrointestinal endoscopy. The patient was diagnosed with advanced gastric cancer 3.5 months after presentation for chylothorax.

摘要

乳糜胸是指脂质在胸腔内积聚。很少有报告描述由胃癌引起的乳糜胸。一名45岁女性出现进行性淋巴水肿和双侧乳糜胸。尽管反复进行胸腔穿刺以缓解其呼吸困难,但她腋窝淋巴结的肿胀变得明显。正电子发射断层扫描/计算机断层扫描显示这些淋巴结中有氟脱氧葡萄糖积聚,淋巴结活检显示印戒细胞癌。原发部位是胃体部的0-IIc型病变,仅通过上消化道内镜检查发现。该患者在因乳糜胸就诊3.5个月后被诊断为晚期胃癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae05/6875443/1dc5111e2544/1349-7235-58-3143-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae05/6875443/7cc22dd1a024/1349-7235-58-3143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae05/6875443/87be479c736b/1349-7235-58-3143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae05/6875443/c4f9f5332e9a/1349-7235-58-3143-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae05/6875443/1dc5111e2544/1349-7235-58-3143-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae05/6875443/7cc22dd1a024/1349-7235-58-3143-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae05/6875443/87be479c736b/1349-7235-58-3143-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae05/6875443/c4f9f5332e9a/1349-7235-58-3143-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ae05/6875443/1dc5111e2544/1349-7235-58-3143-g004.jpg

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Clin J Gastroenterol. 2023 Dec;16(6):822-828. doi: 10.1007/s12328-023-01851-5. Epub 2023 Sep 22.
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Chylothorax due to thrombosis of the jugular and subclavian veins in a patient with gastric cancer: a case report.

本文引用的文献

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A phase III trial comparing oral S-1/cisplatin and intravenous 5-fluorouracil/cisplatin in patients with untreated diffuse gastric cancer.一项比较未经治疗的弥漫性胃癌患者口服 S-1/顺铂和静脉注射氟尿嘧啶/顺铂的 III 期临床试验。
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Double trouble: Biochemically confirmed bilateral chylothorax with positive pleural fluid cytology due to breast adenocarcinoma.双重麻烦:经生化证实的双侧乳糜胸,伴有因乳腺腺癌导致的胸腔积液细胞学检查呈阳性。
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Pleural Effusion as the Initial Presentation of Gastric Adenocarcinoma: A Case Report.胸腔积液为首发表现的胃腺癌 1 例报告
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III 期研究比较奥沙利铂加 S-1 与顺铂加 S-1 治疗初治晚期胃癌患者的疗效。
Ann Oncol. 2015 Jan;26(1):141-148. doi: 10.1093/annonc/mdu472. Epub 2014 Oct 14.
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Chylothorax in gastric adenocarcinoma: A case report and systematic review of the English literature.胃腺癌并发乳糜胸:一例报告及英文文献系统综述
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[Chylothorax in a patient with advanced gastric cancer and mediastinal lymph node metastasis causing thoracic duct obstruction].
Nihon Shokakibyo Gakkai Zasshi. 2013 Nov;110(11):1943-9.
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Current views on diagnostic approach and treatment of lymphedema.目前关于淋巴水肿的诊断方法和治疗的观点。
Am J Med. 2012 Feb;125(2):134-40. doi: 10.1016/j.amjmed.2011.06.032.
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[A case of gastric cancer with bilateral chylothorax].[一例伴有双侧乳糜胸的胃癌病例]
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Gastric signet-ring cell adenocarcinoma presenting with left arm deep-vein thrombosis and bilateral chylothorax.胃印戒细胞腺癌伴左臂深静脉血栓形成及双侧乳糜胸。
Clin Appl Thromb Hemost. 2008 Oct;14(4):476-80. doi: 10.1177/1076029607309181. Epub 2008 Feb 8.
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A case of gastric cancer detected incidentally following to chylothorax, followed by change in the appearance of pleural effusion with cancer progression.一例乳糜胸后偶然发现的胃癌,随后随着癌症进展胸腔积液外观发生改变。
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