Olesiak-Banska Joanna, Waszkielewicz Magdalena, Obstarczyk Patryk, Samoc Marek
Advanced Materials Engineering and Modelling Group, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.
Chem Soc Rev. 2019 Jul 29;48(15):4087-4117. doi: 10.1039/c8cs00849c.
This review provides a comprehensive description of nonlinear optical (NLO) properties of gold nanoparticles, which can be used in biological applications. The main focus is placed on two-photon absorption (2PA) and two-photon excited photoluminescence (2PEL) - the processes crucial for multiphoton microscopy, which allows deeper imaging of the material and causes less damage to the biological samples in comparison to conventional (one-photon) microscopy. We present the basics of 2PA measurement techniques and a summary of recent achievements in the understanding of multiphoton excitation and the resulting photoluminescence in gold nanoparticles, both plasmonic ones and small nanoclusters with molecule-like properties. The examples of 2PA applications in bioimaging are also presented, with a comment on future challenges and applications.
本综述全面描述了可用于生物应用的金纳米颗粒的非线性光学（NLO）特性。主要重点放在双光子吸收（2PA）和双光子激发光致发光（2PEL）上——这两个过程对多光子显微镜至关重要，与传统（单光子）显微镜相比，多光子显微镜能够对材料进行更深层次的成像，并且对生物样品造成的损伤更小。我们介绍了2PA测量技术的基础知识，以及在理解金纳米颗粒（包括等离子体金纳米颗粒和具有分子样性质的小纳米团簇）中的多光子激发及由此产生的光致发光方面的最新成果总结。还给出了2PA在生物成像中的应用实例，并对未来的挑战和应用进行了评论。
