Kavli Institute for Systems Neuroscience, Centre for Neural Computation, Egil and Pauline Braathen and Fred Kavli Centre for Cortical Microcircuits, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
Eur J Neurosci. 2019 Nov;50(10):3627-3662. doi: 10.1111/ejn.14511. Epub 2019 Jul 29.
The identification of neuronal markers, that is, molecules selectively present in subsets of neurons, contributes to our understanding of brain areas and the networks within them. Specifically, recognizing the distribution of different neuronal markers facilitates the identification of borders between functionally distinct brain areas. Detailed knowledge about the localization and physiological significance of neuronal markers may also provide clues to generate new hypotheses concerning aspects of normal and abnormal brain functioning. Here, we provide a comprehensive review on the distribution within the entorhinal cortex of neuronal markers and the morphology of the neurons they reveal. Emphasis is on the comparative distribution of several markers, with a focus on, but not restricted to rodent, monkey and human data, allowing to infer connectional features, across species, associated with these markers, based on what is revealed by mainly rodent data. The overall conclusion from this review is that there is an emerging pattern in the distribution of neuronal markers in the entorhinal cortex when aligning data along a comparable coordinate system in various species.
神经元标记物的鉴定，即选择性存在于神经元亚群中的分子，有助于我们了解大脑区域及其内部网络。具体来说，识别不同神经元标记物的分布有助于确定功能不同的大脑区域之间的边界。关于神经元标记物的定位和生理意义的详细知识也可能为生成关于正常和异常大脑功能的新假设提供线索。在这里，我们提供了一个关于内嗅皮层中神经元标记物的分布和它们所揭示的神经元形态的综合综述。重点是比较几种标记物的分布，重点是，但不限于啮齿动物、猴子和人类的数据，以便根据主要基于啮齿动物数据揭示的内容，推断出与这些标记物相关的跨物种的连接特征。从这个综述中得出的总体结论是，当沿着不同物种的可比坐标系排列数据时，内嗅皮层中神经元标记物的分布呈现出一种新兴模式。
