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来自[植物名称]地下部分的甾体糖苷及其在小鼠体内的抗炎活性。 (你提供的原文中“and their anti-inflammatory activities in mice.”前缺少植物名称,请补充完整以便更准确翻译。)

Steroidal glycosides from the underground parts of and their anti-inflammatory activities in mice.

作者信息

Chu Hong-Biao, Li Nan-Nan, Zhang Zong-Ping, Hu Xiao-Yue, Yu Cai-Yun, Hua Lei

机构信息

Department of Pharmacy, School of Medicine, Jinggangshan University, Ji'an, Jiangxi, China.

出版信息

Nat Prod Res. 2021 Jun;35(11):1766-1774. doi: 10.1080/14786419.2019.1638379. Epub 2019 Jul 11.

Abstract

Two new pregnane glycosides, 2α, 3β-dihydroxy-5α-pregn-16-en-20-one-3-O-{α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)]-β-D-galactopyranoside} () and 2α, 3β-dihydroxy-5α-pregn-16-en-20-one-3-O-{β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside}(), have been isolated along with two known spirostanol saponins from the underground parts of . Their structures were elucidated on the basis of chemical and spectral evidence. The anti-inflammatory activities of these steroidal glycosides were evaluated using a xylene-induced ear edema model. Our results indicated that the compounds exhibited promising anti-inflammatory activities.

摘要

从[植物名称]的地下部分分离出了两种新的孕甾烷糖苷,即2α, 3β - 二羟基 - 5α - 孕 - 16 - 烯 - 20 - 酮 - 3 - O - {α - L - 鼠李糖基 - (1→2) - [β - D - 葡萄糖基 - (1→4)] - β - D - 半乳糖苷}()和2α, 3β - 二羟基 - 5α - 孕 - 16 - 烯 - 20 - 酮 - 3 - O - {β - D - 葡萄糖基 - (1→2) - [β - D - 木糖基 - (1→3)] - β - D - 葡萄糖基 - (1→4) - β - D - 半乳糖苷}(),以及两种已知的螺旋甾烷醇皂苷。基于化学和光谱证据阐明了它们的结构。使用二甲苯诱导的耳肿胀模型评估了这些甾体糖苷的抗炎活性。我们的结果表明这些化合物表现出有前景的抗炎活性。

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