Li Hui, Yue Bing
Department of Bone and Joint Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
World J Stem Cells. 2019 Jun 26;11(6):322-336. doi: 10.4252/wjsc.v11.i6.322.
Antimicrobial drugs of several classes play an important role in the treatment of bone and joint infections. In addition to fighting pathogenic microorganisms, the effects of drugs on local tissues and cells are also related to the course and prognosis of bone and joint infections. The multi-directional differentiation potential of bone marrow-derived mesenchymal stem cells (MSCs) is essential for tissue repair after local injury, which is directly related to the recovery of bone, cartilage, and medullary adipose tissue. Our previous studies and the literature indicate that certain antimicrobial agents can regulate the differentiation potential of bone marrow-derived MSCs. Here, in order to systematically analyze the effects of various antimicrobial drugs on local tissue regeneration, we comprehensively review the studies on the effects of these drugs on MSC differentiation, and classify them according to the three differentiation directions (osteogenesis, chondrogenesis, and adipogenesis). Our review demonstrates the specific effects of different antimicrobial agents on bone marrow-derived MSCs and the range of concentrations at which they work, and provides a basis for drug selection at different sites of infection.
几类抗菌药物在骨与关节感染的治疗中发挥着重要作用。除了对抗病原微生物外，药物对局部组织和细胞的作用也与骨与关节感染的病程及预后相关。骨髓间充质干细胞（MSCs）的多向分化潜能对于局部损伤后的组织修复至关重要，这与骨、软骨和骨髓脂肪组织的恢复直接相关。我们之前的研究及文献表明，某些抗菌药物可调节骨髓来源MSCs的分化潜能。在此，为了系统分析各种抗菌药物对局部组织再生的影响，我们全面综述了这些药物对MSCs分化影响的研究，并根据三个分化方向（成骨、成软骨和脂肪生成）对其进行分类。我们的综述展示了不同抗菌药物对骨髓来源MSCs的具体作用及其发挥作用的浓度范围，并为不同感染部位的药物选择提供了依据。
