Li Yuan, Liu Shousheng, Gao Yuqiang, Ma Huan, Zhan Shuhui, Yang Yan, Xin Yongning, Xuan Shiying
Department of Gastroenterology, Qingdao Municipal Hospital, Qingdao, China.
Central Laboratories, Qingdao Municipal Hospital, Qingdao, China.
J Clin Transl Hepatol. 2019 Jun 28;7(2):99-105. doi: 10.14218/JCTH.2019.00010. Epub 2019 May 4.
Colorectal cancer is associated with non-alcoholic fatty liver disease (NAFLD) and other metabolic syndromes, such as obesity, abnormal blood glucose, and dyslipidemia. The relationship of NAFLD and colorectal adenoma, which is the precursor of colorectal cancer, is worthy of discussion. The aim of this study was to investigate the association between colorectal adenoma and NAFLD, colorectal adenoma and metabolic syndrome in a Chinese Han population. This retrospective study analyzed the relationship between NAFLD and colorectal adenoma in 1089 patients in Qingdao municipal hospital. Subjects were divided into a colorectal adenoma group ( = 267) and a control group ( = 822). NAFLD and the controlled attenuation parameter (CAP) value were determined by abdominal ultrasound and FibroScan. Patients with NAFLD in the colorectal adenoma group and the control group represented 142 cases (53.2%) and 360 cases (43.8%), respectively. The mean CAP value in the colorectal adenoma group was significantly higher than that in the control group. The values of body mass index, triglyceride, high-density lipoprotein cholesterol, aspartate aminotransferase, fasting plasma glucose, and uric acid were also significantly higher in the colorectal adenoma group than in the control group. Multifactor logistic regression analysis showed that the sex, NAFLD, CAP, body mass index, triglyceride, aspartate aminotransferase, and fasting plasma glucose were significant risk factors for colorectal adenoma. Besides, NAFLD and CAP value were significant risk factors for colorectal adenoma in males but not in females. NAFLD and metabolic syndrome were tightly associated with the risk of colorectal adenoma in this Chinese Han population. The effect of NAFLD on colorectal adenoma was prominent in males rather than in females.
结直肠癌与非酒精性脂肪性肝病（NAFLD）以及其他代谢综合征相关，如肥胖、血糖异常和血脂异常。NAFLD与作为结直肠癌前体的结直肠腺瘤之间的关系值得探讨。本研究的目的是调查中国汉族人群中结直肠腺瘤与NAFLD、结直肠腺瘤与代谢综合征之间的关联。这项回顾性研究分析了青岛市立医院1089例患者中NAFLD与结直肠腺瘤之间的关系。受试者分为结直肠腺瘤组（n = 267）和对照组（n = 822）。通过腹部超声和FibroScan测定NAFLD和受控衰减参数（CAP）值。结直肠腺瘤组和对照组中患有NAFLD的患者分别为142例（53.2%）和360例（43.8%）。结直肠腺瘤组的平均CAP值显著高于对照组。结直肠腺瘤组的体重指数、甘油三酯、高密度脂蛋白胆固醇、天冬氨酸转氨酶、空腹血糖和尿酸值也显著高于对照组。多因素逻辑回归分析表明，性别、NAFLD、CAP、体重指数、甘油三酯、天冬氨酸转氨酶和空腹血糖是结直肠腺瘤的显著危险因素。此外，NAFLD和CAP值是男性结直肠腺瘤的显著危险因素，而在女性中则不是。在这个中国汉族人群中，NAFLD和代谢综合征与结直肠腺瘤风险密切相关。NAFLD对结直肠腺瘤的影响在男性中比在女性中更为突出。
