Xiong Jingfang, Wu Yijun, Chen Dongya, Zhang Zhaolin, Liu Yihui, Luo Jiandong, Xu Hong
Department of Geriatrics, Hangzhou Red Cross Hospital, Hangzhou City, Zhejiang Province, China.
The 2nd Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province, China.
BMC Gastroenterol. 2024 Apr 22;24(1):138. doi: 10.1186/s12876-024-03220-z.
To analyze the risk factors associated with colorectal adenoma and to investigate the associations of metabolism-related fatty liver disease (MAFLD) with obesity, colorectal adenoma and high-risk adenoma.
A total of 1395 subjects were enrolled and divided into a colorectal adenoma group (593 subjects) and a control group (802 subjects) according to the inclusion and exclusion criteria. The characteristics of patients in the colorectal adenoma group and the control group were compared by the chi-square test. Univariate and multivariate logistic analyses were used to analyze independent risk factors and associations with different MAFLD subtypes. Colorectal adenoma characteristics and the proportion of patients with high-risk colorectal adenoma were also compared.
High-density lipoprotein (HDL-C) was significantly lower in patients in the colorectal adenoma group than in those in the control group (P < 0.001). Logistic regression analysis revealed that age, obesity status, central obesity status, hypertension status, diabetes status, fatty liver status, smoking history, BMI, waist circumference, triglyceride level, HDL-C level, fasting blood glucose level and degree of hepatic steatosis were all independent risk factors for colorectal adenoma. Notably, MAFLD was associated with a significantly increased risk of colorectal adenoma in patients with central obesity (P < 0.001). In addition, obesity, central obesity, diabetes, fatty liver and degree of hepatic steatosis were all shown to be independent risk factors for high-risk colorectal adenoma. In addition, a greater proportion of MAFLD patients with central obesity than those without central obesity had high-risk colorectal adenoma.
MAFLD and central obesity are independently associated with the development of colorectal adenoma. MAFLD with central obesity is associated with an increased risk of colorectal adenoma and high-risk adenoma.
分析与结直肠腺瘤相关的危险因素，并探讨代谢相关脂肪性肝病（MAFLD）与肥胖、结直肠腺瘤及高危腺瘤之间的关联。
共纳入1395名受试者，根据纳入和排除标准分为结直肠腺瘤组（593名受试者）和对照组（802名受试者）。采用卡方检验比较结直肠腺瘤组和对照组患者的特征。采用单因素和多因素逻辑回归分析独立危险因素以及与不同MAFLD亚型的关联。还比较了结直肠腺瘤的特征及高危结直肠腺瘤患者的比例。
结直肠腺瘤组患者的高密度脂蛋白（HDL-C）显著低于对照组（P＜0.001）。逻辑回归分析显示，年龄、肥胖状态、中心性肥胖状态、高血压状态、糖尿病状态、脂肪肝状态、吸烟史、体重指数（BMI）、腰围、甘油三酯水平、HDL-C水平、空腹血糖水平及肝脂肪变性程度均为结直肠腺瘤的独立危险因素。值得注意的是，MAFLD与中心性肥胖患者患结直肠腺瘤的风险显著增加相关（P＜0.001）。此外，肥胖、中心性肥胖、糖尿病、脂肪肝及肝脂肪变性程度均被证明是高危结直肠腺瘤的独立危险因素。此外，与无中心性肥胖的MAFLD患者相比，有中心性肥胖的MAFLD患者患高危结直肠腺瘤的比例更高。
MAFLD和中心性肥胖与结直肠腺瘤的发生独立相关。伴有中心性肥胖的MAFLD与结直肠腺瘤及高危腺瘤风险增加相关。
