Pruul H, Kriek G, McDonald P J
Department of Clinical Microbiology, Flinders Medical Centre, Bedford Park, South Australia.
J Antimicrob Chemother. 1988 Feb;21 Suppl B:19-27. doi: 10.1093/jac/21.suppl_b.19.
The effect of enoxacin upon the interaction in vitro of human polymorphonuclear leucocytes with Streptococcus pneumoniae and Pseudomonas aeruginosa was examined. Synergistic killing of these two species of bacteria was observed in the presence of neutrophils and concentrations of enoxacin above the MIC. Enoxacin was able to kill intracellular Str. pneumoniae and Staphylococcus aureus. The activity of glucose-glucose oxidase, an oxygen-dependent bactericidal system which mimics part of the bactericidal system of human neutrophils, was enhanced by pretreatment with enoxacin and several other antibiotics. The effect of antibiotic pretreatment upon the bactericidal activity of an acid extract of neutrophil granules was variable.
研究了依诺沙星对人多形核白细胞与肺炎链球菌及铜绿假单胞菌体外相互作用的影响。在嗜中性粒细胞存在且依诺沙星浓度高于最低抑菌浓度时，观察到对这两种细菌的协同杀伤作用。依诺沙星能够杀伤细胞内的肺炎链球菌和金黄色葡萄球菌。葡萄糖 - 葡萄糖氧化酶是一种模拟人嗜中性粒细胞部分杀菌系统的需氧杀菌系统，用依诺沙星和其他几种抗生素预处理可增强其活性。抗生素预处理对嗜中性粒细胞颗粒酸性提取物杀菌活性的影响各不相同。
