Pruul H, Hill N, McDonald P J
J Antimicrob Chemother. 1984 Sep;14 Suppl C:19-31. doi: 10.1093/jac/14.suppl_c.19.
This report examines the effects of exposure to enoxacin on interactions of bacteria and neutrophils. Pretreatment of Streptococcus pneumoniae and Pseudomonas aeruginosa with x 1/2 to x4 the MIC of enoxacin had no enhancing effect upon phagocytic killing when the antibiotic was not present. Phagocytic killing was synergistically enhanced when enoxacin was continually present although this was not manifested in increased phagocytosis. The enhanced killing was abrogated by disruption of bacterial opsonization, internalization and intraleukocytic killing processes of polymorphonuclear leukocytes. These observations indicate that the synergistic killing of Str. pneumoniae and Ps. aeruginosa by enoxacin and human neutrophils is due to enhanced intracellular killing and not an increase in phagocytosis.
本报告研究了暴露于依诺沙星对细菌与中性粒细胞相互作用的影响。用依诺沙星最低抑菌浓度（MIC）的1/2至4倍预处理肺炎链球菌和铜绿假单胞菌，在无抗生素存在时，对吞噬杀伤无增强作用。当持续存在依诺沙星时，吞噬杀伤作用协同增强，尽管这并未表现为吞噬作用增加。多形核白细胞的细菌调理作用、内化作用和白细胞内杀伤过程被破坏后，增强的杀伤作用被消除。这些观察结果表明，依诺沙星与人中性粒细胞对肺炎链球菌和铜绿假单胞菌的协同杀伤作用是由于细胞内杀伤作用增强，而非吞噬作用增加。
