依诺沙星：丝状大肠杆菌细胞的强效诱导剂（一则笔记）
Enoxacin: a potent inducer of filamentous Escherichia coli cells (a note).
作者信息
Uri J V, Actor P
出版信息
Acta Microbiol Hung. 1985;32(2):197-200.
PMID:3933273
Abstract
Enoxacin (CI-919; AT-2266), a new naphthyridine derivative was found to induce morphologic changes at very low concentrations in Escherichia coli but not in Staphylococcus aureus and Pseudomonas aeruginosa cells. The development of the long filamentous forms observed with nalidixic acid is most probably a consequence of inhibition of DNA synthesis. The phenomenon may, however, not be the sole mechanism of the broad-spectrum antimicrobial activity of enoxacin.
摘要
依诺沙星（CI - 919；AT - 2266），一种新型萘啶衍生物，被发现能在极低浓度下诱导大肠杆菌发生形态变化，但对金黄色葡萄球菌和铜绿假单胞菌细胞无此作用。萘啶酸所观察到的长丝状形态的形成很可能是DNA合成受到抑制的结果。然而，这种现象可能并非依诺沙星广谱抗菌活性的唯一机制。
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