Kuna Lucija, Jakab Jelena, Smolic Robert, Wu George Y, Smolic Martina
Department of Pharmacology and Biochemistry, Faculty of Dental Medicine and Health, J. J. Strossmayer University of Osijek, Osijek, Croatia.
Department of Pathophysiology and Physiology with Immunology, Faculty of Dental Medicine and Health, J. J. Strossmayer University of Osijek, Osijek, Croatia.
J Clin Transl Hepatol. 2019 Jun 28;7(2):172-182. doi: 10.14218/JCTH.2018.00049. Epub 2019 Apr 21.
Hepatitis C virus (HCV) has been shown to affect many tissues other than liver. However, of the many extrahepatic manifestations (EMs) that have been associated with HCV, including cryoglobulinemia, lymphoma, insulin resistance, type 2 diabetes and neurological disorders, only a few have been shown to be directly related to HCV infection of extrahepatic tissues. HCV-triggered immune-mediated mechanisms account for most of the EMs. It is estimated that up to 74% of patients with chronic hepatitis C can develop at least one EM. All HCV patients with EMs should be considered for antiviral therapy, although not all will resolve with sustained virological response.
丙型肝炎病毒（HCV）已被证明会影响肝脏以外的许多组织。然而，在与HCV相关的众多肝外表现（EMs）中，包括冷球蛋白血症、淋巴瘤、胰岛素抵抗、2型糖尿病和神经疾病，只有少数被证明与肝外组织的HCV感染直接相关。HCV触发的免疫介导机制是大多数EMs的原因。据估计，高达74%的慢性丙型肝炎患者会出现至少一种EM。所有有EMs的HCV患者都应考虑进行抗病毒治疗，尽管并非所有患者都会因持续病毒学应答而痊愈。
