Kogan Rosalie V, de Jong Bas A, Renken Remco J, Meles Sanne K, van Snick Paul J H, Golla Sandeep, Rijnsdorp Sjoerd, Perani Daniela, Leenders Klaus L, Boellaard Ronald
Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Neuroimaging Center, Department of Neuroscience, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Alzheimers Dement (Amst). 2019 Jun 22;11:472-482. doi: 10.1016/j.dadm.2019.04.002. eCollection 2019 Dec.
The implementation of spatial-covariance [F]fluorodeoxyglucose positron emission tomography-based disease-related metabolic brain patterns as biomarkers has been hampered by intercenter imaging differences. Within the scope of the JPND-PETMETPAT working group, we illustrate the impact of these differences on Parkinson's disease-related pattern (PDRP) expression scores.
Five healthy controls, 5 patients with idiopathic rapid eye movement sleep behavior disorder, and 5 patients with Parkinson's disease were scanned on one positron emission tomography/computed tomography system with multiple image reconstructions. In addition, one Hoffman 3D Brain Phantom was scanned on several positron emission tomography/computed tomography systems using various reconstructions. Effects of image contrast on PDRP scores were also examined.
Human and phantom raw PDRP scores were systematically influenced by scanner and reconstruction effects. PDRP scores correlated inversely to image contrast. A Gaussian spatial filter reduced contrast while decreasing intercenter score differences.
Image contrast should be considered in harmonization efforts. A Gaussian filter may reduce noise and intercenter effects without sacrificing sensitivity. Phantom measurements will be important for correcting PDRP score offsets.
基于空间协方差的[F]氟脱氧葡萄糖正电子发射断层扫描的疾病相关代谢脑模式作为生物标志物的应用受到不同中心成像差异的阻碍。在日本国立痴呆症研究项目 - 正电子发射断层扫描代谢模式（JPND - PETMETPAT）工作组的范围内，我们阐述了这些差异对帕金森病相关模式（PDRP）表达分数的影响。
在一台具有多种图像重建功能的正电子发射断层扫描/计算机断层扫描系统上，对5名健康对照者、5名特发性快速眼动睡眠行为障碍患者和5名帕金森病患者进行扫描。此外，使用各种重建方法在多个正电子发射断层扫描/计算机断层扫描系统上对一个霍夫曼3D脑模型进行扫描。还研究了图像对比度对PDRP分数的影响。
人体和模型的原始PDRP分数受到扫描仪和重建效果的系统性影响。PDRP分数与图像对比度呈负相关。高斯空间滤波器在降低不同中心分数差异的同时降低了对比度。
在协调工作中应考虑图像对比度。高斯滤波器可以在不牺牲灵敏度的情况下降低噪声和不同中心的影响。模型测量对于校正PDRP分数偏移将很重要。
