Lekshmi Manjusha, Ammini Parvathi, Adjei Jones, Sanford Leslie M, Shrestha Ugina, Kumar Sanath, Varela Manuel F
QC Laboratory, Harvest and Post Harvest Technology Division, ICAR-Central Institute of Fisheries Education (CIFE), Seven Bungalows, Versova, Andheri (W), Mumbai, 400061, India.
CSIR-National Institute of Oceanography (NIO), Regional Centre, Dr. Salim Ali Road, Kochi, 682018, India.
AIMS Microbiol. 2018 Jan 4;4(1):1-18. doi: 10.3934/microbiol.2018.1.1. eCollection 2018.
Variants of the microorganism which are resistant to antimicrobial agents exist as causative agents of serious infectious disease and constitute a considerable public health concern. One of the main antimicrobial resistance mechanisms harbored by pathogens is exemplified by integral membrane transport systems that actively remove antimicrobial agents from bacteria where the cytoplasmic drug targets reside, thus allowing the bacteria to survive and grow. An important class of solute transporter proteins, called the major facilitator superfamily, includes related and homologous passive and secondary active transport systems, many of which are antimicrobial efflux pumps. Transporters of the major facilitator superfamily, which confer antimicrobial efflux and bacterial resistance in , are good targets for development of resistance-modifying agents, such as efflux pump inhibition. Such modulatory action upon these antimicrobial efflux systems of the major facilitator superfamily in may circumvent resistance and restore the clinical efficacy of therapy towards infection.
对抗菌药物具有抗性的微生物变体作为严重传染病的病原体存在，并构成了相当大的公共卫生问题。病原体所具有的主要抗菌抗性机制之一以完整膜转运系统为例，该系统能主动将抗菌药物从细胞质药物靶点所在的细菌中清除，从而使细菌得以存活和生长。一类重要的溶质转运蛋白，称为主要易化子超家族，包括相关的同源被动和次级主动转运系统，其中许多是抗菌外排泵。主要易化子超家族的转运蛋白在……中赋予抗菌外排和细菌抗性，是开发抗性修饰剂（如外排泵抑制剂）的良好靶点。对主要易化子超家族在……中的这些抗菌外排系统的这种调节作用可能会规避抗性，并恢复针对……感染的治疗临床疗效。
