藻类代谢产物作为抗耐甲氧西林金黄色葡萄球菌（MRSA）的新型疗法：综述

Algal Metabolites as Novel Therapeutics Against Methicillin-Resistant (MRSA): A Review.

作者信息

Ibraheem Ibraheem Borie M, Alharbi Reem Mohammed, Abdel-Raouf Neveen, Al-Enazi Nouf Mohammad, Alsamhary Khawla Ibrahim, Ali Hager Mohammed

机构信息

Botany and Microbiology Department, Faculty of Science, Beni-Suef University, Beni-Suef 62521, Egypt.

Biology Department, Science College, University of Hafr Al-Batin, Hafr Al-Batin 39524, Saudi Arabia.

出版信息

Pharmaceutics. 2025 Jul 30;17(8):989. doi: 10.3390/pharmaceutics17080989.

DOI:10.3390/pharmaceutics17080989

PMID:40871012

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12389059/

Abstract

Methicillin-resistant (MRSA), a multidrug-resistant pathogen, poses a significant threat to global healthcare. This review evaluates the potential of marine algal metabolites as novel antibacterial agents against MRSA. We explore the clinical importance of , the emergence of MRSA as a "superbug", and its resistance mechanisms, including target modification, drug inactivation, efflux pumps, biofilm formation, and quorum sensing. The limitations of conventional antibiotics (e.g., β-lactams, vancomycin, macrolides) are discussed, alongside the promise of algal-derived compounds such as fatty acids, pigments, polysaccharides, terpenoids, and phenolic compounds. These metabolites exhibit potent anti-MRSA activity by disrupting cell division (via FtsZ inhibition), destabilizing membranes, and inhibiting protein synthesis and metabolic pathways, effectively countering multiple resistance mechanisms. Leveraging advances in algal biotechnology, this review highlights the untapped potential of marine algae to drive innovative, sustainable therapeutic strategies against antibiotic resistance.

摘要

耐甲氧西林金黄色葡萄球菌（MRSA）是一种多重耐药病原体，对全球医疗保健构成重大威胁。本综述评估了海洋藻类代谢产物作为抗MRSA新型抗菌剂的潜力。我们探讨了MRSA作为“超级细菌”出现的临床重要性及其耐药机制，包括靶点修饰、药物失活、外排泵、生物膜形成和群体感应。讨论了传统抗生素（如β-内酰胺类、万古霉素、大环内酯类）的局限性，以及藻类衍生化合物（如脂肪酸、色素、多糖、萜类化合物和酚类化合物）的前景。这些代谢产物通过破坏细胞分裂（通过抑制FtsZ）、破坏细胞膜稳定性以及抑制蛋白质合成和代谢途径，展现出强大的抗MRSA活性，有效对抗多种耐药机制。利用藻类生物技术的进展，本综述强调了海洋藻类在推动针对抗生素耐药性的创新、可持续治疗策略方面尚未开发的潜力。