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从……的树脂中提取的具有生物活性的西松烷类化合物sacraoxides A - G

Sacraoxides A-G, Bioactive Cembranoids from Gum Resin of .

作者信息

Zhang Bingyang, Liu Di, Ji Wenyue, Otsuki Kouharu, Higai Koji, Zhao Feng, Li Wei, Koike Kazuo, Qiu Feng

机构信息

School of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, China.

Faculty of Pharmaceutical Sciences, Toho University, Tokyo, Japan.

出版信息

Front Chem. 2021 Mar 30;9:649287. doi: 10.3389/fchem.2021.649287. eCollection 2021.

DOI:10.3389/fchem.2021.649287
PMID:33869144
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8044883/
Abstract

Seven undescribed cembranoids, sacraoxides A-G (-) were isolated from the gum resin of . Their structures were elucidated by extensive physicochemical and spectroscopic analysis, as well as ECD calculation, modified Mosher's method and X-ray diffraction crystallography. Compounds and exhibited inhibitory activities on nitric oxide (NO) production induced by lipopolysaccharide in RAW264.7 cells with IC values of 24.9 ± 1.7 and 36.4 ± 2.9 M.

摘要

从……的树胶脂中分离出七种未描述的西松烷类化合物，即sacraoxides A - G（-）。通过广泛的物理化学和光谱分析，以及电子圆二色光谱（ECD）计算、改良的莫舍方法和X射线衍射晶体学确定了它们的结构。化合物……和……对RAW264.7细胞中脂多糖诱导的一氧化氮（NO）产生具有抑制活性，IC值分别为24.9±1.7和36.4±2.9 μM。 （原文中化合物处有缺失信息）

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