利用光声成像技术探索治疗窗：药物输送的新进展。
Listening for the therapeutic window: Advances in drug delivery utilizing photoacoustic imaging.
机构信息
Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, United States.
Department of NanoEngineering, University of California, San Diego, La Jolla, CA 92093, United States; Materials Science and Engineering Program, University of California, San Diego, La Jolla, CA 92093, United States.
出版信息
Adv Drug Deliv Rev. 2019 Apr;144:78-89. doi: 10.1016/j.addr.2019.07.003. Epub 2019 Jul 8.
Abstract
The preclinical landscape of photoacoustic imaging has experienced tremendous growth in the past decade. This non-invasive imaging modality augments the spatiotemporal capabilities of ultrasound with optical contrast. While it has principally been investigated for diagnostic applications, many recent reports have described theranostic delivery systems and drug monitoring strategies using photoacoustics. Here, we provide an overview of the progress to date while highlighting work in three specific areas: theranostic nanoparticles, real-time drug monitoring, and stem cell ("living drug") tracking. Additionally, we discuss the challenges that remain to be addressed in this burgeoning field.
摘要
在过去的十年中，光声成象的临床前领域经历了飞速的发展。这种非侵入性的成像方式用光学对比增强了超声波的时空分辨率。虽然它主要用于诊断应用，但最近的许多报告都描述了使用光声的治疗学输送系统和药物监测策略。在这里，我们提供了迄今为止的进展概述，同时重点介绍了三个特定领域的工作：治疗学纳米粒子、实时药物监测和干细胞（“活药物”）跟踪。此外，我们还讨论了这个快速发展的领域中仍然存在的挑战。
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