School of Medicine and Surgery, University of Milan-Bicocca, Milan, Italy, Neurointensive Care, San Gerardo Hospital, ASST-Monza, 20900 Monza, Italy.
Department of Translational Medicine, Università degli Studi del Piemonte Orientale, Via Solaroli 17, 28100 Novara (NO), Italy.
Cells. 2019 Jul 10;8(7):695. doi: 10.3390/cells8070695.
Aneurysmal subarachnoid hemorrhage (SAH) is associated with high morbidity and mortality. In SAH patients, plasma osteopontin (OPN) has been shown to independently predict poor outcome. The aim of the study is to investigate, in a selected population with severe SAH, OPN time course in cerebrospinal fluid (CSF) and plasma during the first week after aneurism rupture, and OPN prognostic value. We included 44 patients with the following criteria: (1) age 18 and 80 years, (2) diagnosis of SAH from cerebral aneurysm rupture, (3) insertion of external ventricular drain. Plasma and CSF were sampled at day 1, 4, and 8. OPN levels, in CSF and plasma, displayed a weak correlation on day 1 and were higher, in CSF, in all time points. Only in poor prognosis patients, OPN levels in CSF significantly increased at day 4 and day 8. Plasma OPN at day 1 and 4 was predictor of poor outcome. In conclusion, plasma and CSF OPN displays a weak correlation, on day 1. The higher levels of OPN found in the CSF compared to plasma, suggest OPN production within the CNS after SAH. Furthermore, plasma OPN, at day 1 and 4, seems to be an independent predictor of poor outcome.
颅内动脉瘤性蛛网膜下腔出血（SAH）与高发病率和高死亡率相关。在 SAH 患者中，血浆骨桥蛋白（OPN）已被证明可独立预测不良预后。本研究的目的是在破裂后一周内，研究选定的严重 SAH 患者的脑脊液（CSF）和血浆中 OPN 的时间进程，以及 OPN 的预后价值。我们纳入了 44 名符合以下标准的患者：（1）年龄 18 至 80 岁；（2）诊断为颅内动脉瘤破裂所致的 SAH；（3）插入外部脑室引流管。在第 1、4 和 8 天采集血浆和 CSF 样本。CSF 和血浆中的 OPN 水平在第 1 天显示出较弱的相关性，且所有时间点的 CSF 中的 OPN 水平都更高。只有在预后不良的患者中，CSF 中的 OPN 水平在第 4 天和第 8 天才显著升高。第 1 天和第 4 天的血浆 OPN 是预后不良的预测因子。总之，在第 1 天，血浆和 CSF 中的 OPN 显示出较弱的相关性。与血浆相比，CSF 中 OPN 水平更高，提示 SAH 后 CNS 内 OPN 的产生。此外，第 1 天和第 4 天的血浆 OPN 似乎是不良预后的独立预测因子。
