Department of Molecular Sciences, The University of Western Australia, Crawley, Western Australia, Australia.
Medela AG, Baar, Switzerland.
Arch Dis Child Fetal Neonatal Ed. 2020 May;105(3):266-269. doi: 10.1136/archdischild-2018-316551. Epub 2019 Jul 11.
To determine the impact of the pumping regimes of women with preterm infants on the daily milk production, and on the short-term rate of milk synthesis during early lactation to support evidence-based recommendations for optimising milk production.
Mothers of preterm infants (n=25) recorded start time, finish time and expression volumes from every breast expression on days 10, 15-20 postpartum.
Expressing more often than five times per day did not result in a significant increase in daily milk production. Milk volume per expression per breast increased for intervals between expressions of between 2and6 hours then reached a plateau when the interval between expression was 7 hours or longer. The short-term rate of milk synthesis decreased as the interval between expressions increased until about 7.5 hours at which point it begun to increase (p value associated with interval between expressions^2<0.001).
The strong inverse association between the short-term rate of milk synthesis and the interval between expressions for intervals up to 7 hours suggest that the maximum interval between expressions should be 7 hours. Data suggest that, on average, the mothers should express at least five times a day to maximise daily milk production. Considering inter-individual variation, determination of an individual mother's maximum interval between expressions that does not compromise the short-term rate of milk synthesis will help to optimise daily milk production while minimising the demands on the mother's time.
确定早产儿母亲的挤奶方案对其每日泌乳量和泌乳早期短期合成率的影响，为优化泌乳提供循证推荐依据。
母亲们在产后第 10 天、15-20 天记录每次双侧乳房挤奶的起始时间、结束时间和挤出量。
每天挤奶次数多于 5 次并不会显著增加每日泌乳量。双侧乳房每次挤奶的泌乳量在两次挤奶间隔 2-6 小时内逐渐增加，达到 7 小时或更长时间时趋于稳定。随着两次挤奶间隔时间的增加，泌乳短期合成率逐渐下降，当间隔时间约为 7.5 小时时开始上升（两次挤奶间隔时间的平方与 p 值的关系<0.001）。
在 7 小时以内的两次挤奶间隔时间与泌乳短期合成率之间存在强烈的负相关关系，这表明两次挤奶的最大间隔时间应为 7 小时。数据表明，为了最大限度地提高每日泌乳量，母亲们平均每天应至少挤奶 5 次。考虑到个体差异，确定不影响泌乳短期合成率的个体母亲的最大挤奶间隔时间有助于在最小化母亲时间投入的同时优化每日泌乳量。
