Martinet M, Fonlupt P, Pacheco H
Experientia. 1978 Sep 15;34(9):1197-9. doi: 10.1007/BF01922955.
Added to a striatal synaptosomal homogenate of rat brain, CDP-choline 10(-4) M inhibits the uptake of norepinephrine (NE), dopamine (DA) and serotonin (5 HT) in a competitive fashion and enhances the uptake of tyrosine and tryptophan; administered to animals, CDP-choline (50 mg/kg/l h/i.v.) inhibits only the in vitro uptake of DA but enhances the uptake of precursors.
将10(-4)M的胞苷二磷酸胆碱添加到大鼠脑纹状体突触体匀浆中,它以竞争性方式抑制去甲肾上腺素(NE)、多巴胺(DA)和5-羟色胺(5-HT)的摄取,并增强酪氨酸和色氨酸的摄取;给动物注射胞苷二磷酸胆碱(50mg/kg/1小时/静脉注射),它仅抑制DA的体外摄取,但增强前体的摄取。