胞苷二磷酸胆碱与大鼠纹状体中生物胺及其前体的突触体转运在体内外的相互作用。
Interaction of CDP-choline with synaptosomal transport of biogenic amines and their precursors in vitro and in vivo in the rat corpus striatum.
作者信息
Martinet M, Fonlupt P, Pacheco H
出版信息
Experientia. 1978 Sep 15;34(9):1197-9. doi: 10.1007/BF01922955.
PMID:31297
Abstract
Added to a striatal synaptosomal homogenate of rat brain, CDP-choline 10(-4) M inhibits the uptake of norepinephrine (NE), dopamine (DA) and serotonin (5 HT) in a competitive fashion and enhances the uptake of tyrosine and tryptophan; administered to animals, CDP-choline (50 mg/kg/l h/i.v.) inhibits only the in vitro uptake of DA but enhances the uptake of precursors.
摘要
将10(-4)M的胞苷二磷酸胆碱添加到大鼠脑纹状体突触体匀浆中，它以竞争性方式抑制去甲肾上腺素（NE）、多巴胺（DA）和5-羟色胺（5-HT）的摄取，并增强酪氨酸和色氨酸的摄取；给动物注射胞苷二磷酸胆碱（50mg/kg/1小时/静脉注射），它仅抑制DA的体外摄取，但增强前体的摄取。
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