Schwartz J, Shklar G, Reid S, Trickler D
Department of Oral Medicine and Oral Pathology, Harvard School of Dental Medicine, Boston, MA 02115.
Nutr Cancer. 1988;11(2):127-34. doi: 10.1080/01635588809513979.
An extract of Spirulina-Dunaliella algae was shown to prevent tumor development in hamster buccal pouch when a 0.1% solution of 7,12-dimethylbenz[a]anthracene (DMBA) in mineral oil was applied topically three times weekly for 28 weeks. The algae extract was delivered by mouth in continued dosages of 140 micrograms in 0.4 ml mineral oil three times per week. After 28 weeks, the animals given vehicle and untreated controls all presented gross tumors of the right buccal pouch. Animals fed canthaxanthin presented a notably and statistically significant reduction in tumor number and size compared with controls. Animals fed beta-carotene demonstrated a smaller but statistically significant reduction in tumor number and size. The algae animals presented a complete absence of gross tumors. However, microscopic sections of the buccal pouch in the algae group showed localized areas of dysplasia and early carcinoma-in-situ undergoing destruction.
当每周三次局部涂抹0.1%的7,12-二甲基苯并[a]蒽（DMBA）于矿物油中，持续28周时，螺旋藻-杜氏藻提取物显示可预防仓鼠颊囊肿瘤的发生。藻类提取物通过口服给药，持续剂量为每周三次，每次0.4毫升矿物油中含140微克。28周后，给予赋形剂的动物和未治疗的对照组均出现右侧颊囊肉眼可见的肿瘤。与对照组相比，喂食角黄素的动物肿瘤数量和大小显著且有统计学意义地减少。喂食β-胡萝卜素的动物肿瘤数量和大小减少幅度较小，但有统计学意义。喂食藻类提取物的动物完全没有肉眼可见的肿瘤。然而，藻类组颊囊的显微切片显示有局部发育异常区域和正在被破坏的早期原位癌。
