Schwartz J, Shklar G
J Oral Maxillofac Surg. 1987 Jun;45(6):510-5. doi: 10.1016/s0278-2391(87)80011-3.
The effect of algae extract on tumor regression was studied. Phycotene (extract of Spirulina and Dunaliella algae) 250 micrograms in 0.1 ml MEM (minimum essential medium) was injected locally into DMBA (7, 12 dimethylbenz(a)anthracene)-induced squamous cell carcinomas of hamster buccal pouch in 20 animals. DMBA-induced carcinomas in 20 hamsters were injected locally with beta carotene 250 micrograms in 0.1 ml MEM; DMBA-induced carcinomas in 20 animals were injected locally with canthaxanthin, 250 micrograms in 0.1 ml MEM, and DMBA-induced carcinomas in 20 animals were injected locally with 13-cis-retinoic acid, 250 micrograms in 0.1 ml MEM. Twenty animals with DMBA-induced carcinomas were sham-injected controls using 0.1 ml MEM. The various agents were injected into the tumor bearing right buccal pouches twice-weekly for four weeks. Total tumor regression was found in 30% of phycotene animals, 20% of beta carotene animals and 15% of canthaxanthin animals after four weeks. Partial tumor regression was found in the remaining 70% of phycotene animals, 80% of beta carotene animals and 85% of canthaxanthin animals. None of the 13-cis-retinoic acid animals had total tumor regression, but 70% showed partial regression. No tumor regression was found in the DMBA control group and the sham-injected group.
研究了藻类提取物对肿瘤消退的影响。将250微克藻青素（螺旋藻和杜氏藻提取物）溶于0.1毫升MEM（最低必需培养基）中，局部注射到20只动物由7,12-二甲基苯并(a)蒽（DMBA）诱导的仓鼠颊囊鳞状细胞癌中。将250微克β-胡萝卜素溶于0.1毫升MEM中，局部注射到20只仓鼠由DMBA诱导的癌中；将250微克角黄素溶于0.1毫升MEM中，局部注射到20只动物由DMBA诱导的癌中；将250微克13-顺式视黄酸溶于0.1毫升MEM中，局部注射到20只动物由DMBA诱导的癌中。20只患有DMBA诱导癌的动物用0.1毫升MEM进行假注射作为对照。每周两次将各种制剂注射到右侧有肿瘤的颊囊中，共四周。四周后，30%的藻青素动物、20%的β-胡萝卜素动物和15%的角黄素动物出现肿瘤完全消退。其余70%的藻青素动物、80%的β-胡萝卜素动物和85%的角黄素动物出现肿瘤部分消退。13-顺式视黄酸组动物均无肿瘤完全消退，但70%出现部分消退。DMBA对照组和假注射组未发现肿瘤消退。
