Chmelař Jindřich, Kotál Jan, Kovaříková Anna, Kotsyfakis Michail
Department of Medical Biology, Faculty of Science, University of South Bohemia in České Budějovice, České Budějovice, Czechia.
Laboratory of Genomics and Proteomics of Disease Vectors, Biology Centre CAS, Institute of Parasitology, České Budějovice, Czechia.
Front Physiol. 2019 Jun 26;10:812. doi: 10.3389/fphys.2019.00812. eCollection 2019.
The last three decades of research into tick salivary components have revealed several proteins with important pharmacological and immunological activities. Two primary interests have driven research into tick salivary secretions: the search for suitable pathogen transmission blocking or "anti-tick" vaccine candidates and the search for novel therapeutics derived from tick salivary components. Intensive basic research in the field of tick salivary gland transcriptomics and proteomics has identified several major protein families that play important roles in tick feeding and overcoming vertebrate anti-tick responses. Moreover, these families contain members with unrealized therapeutic potential. Here we review the major tick salivary protein families exploitable in medical applications such as immunomodulation, inhibition of hemostasis and inflammation. Moreover, we discuss the potential, opportunities, and challenges in searching for novel tick-derived drugs.
过去三十年对蜱唾液成分的研究揭示了几种具有重要药理和免疫活性的蛋白质。对蜱唾液分泌的研究主要有两个方向：寻找合适的病原体传播阻断剂或“抗蜱”疫苗候选物，以及寻找源自蜱唾液成分的新型治疗药物。蜱唾液腺转录组学和蛋白质组学领域的深入基础研究已经确定了几个主要蛋白质家族，它们在蜱的取食和克服脊椎动物的抗蜱反应中发挥着重要作用。此外，这些家族包含具有未实现治疗潜力的成员。在这里，我们综述了在免疫调节、止血和炎症抑制等医学应用中可利用的主要蜱唾液蛋白质家族。此外，我们还讨论了寻找新型蜱源药物的潜力、机会和挑战。
