血清血管内皮生长因子（VEGF）与结直肠癌肿瘤VEGF受体3之间的相关性。
The correlation between serum vascular endothelial growth factor (VEGF) and tumor VEGF receptor 3 in colorectal cancer.
作者信息
Goulart André, Ferreira Carla, Rodrigues Ana, Coimbra Barbara, Sousa Nuno, Leão Pedro
机构信息
General Surgery, Hospital de Braga, Braga, Portugal.
Life and Health Science Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal.
出版信息
Ann Surg Treat Res. 2019 Jul;97(1):15-20. doi: 10.4174/astr.2019.97.1.15. Epub 2019 Jun 26.
PURPOSE
Despite plasma biomarkers offering a number of advantages over tissue-based markers, the relationship between serum vascular endothelial growth factor (VEGF) and VEGF receptor (VEGF-R) tumor expression in colorectal cancer (CRC) is still unclear. This study was designed to establish the relationship between the concentration of serum VEGF and tumor VEGF-R expression in patients with CRC.
METHODS
A prospective study of consecutive patients undergoing elective colorectal surgery during 1 year. Preoperative VEGF was determined by enzyme-linked immunosorbent assay and VEGF-R3 by immunochemistry.
RESULTS
The initial sample included 134 patients with CRC diagnosis. Results showed significant association of serum values of VEGF with VEGF-R3 expression (P < 0.001), even in the presence of confounders (sex, age, body mass index, tumor location, and surgical approach). The estimated effect size was high (η = 0.35).
CONCLUSION
Serum VEGF has a significant correlation with tumoral VEGF-R3 expression in CRC.
目的
尽管血浆生物标志物相对于基于组织的标志物具有许多优势，但血清血管内皮生长因子（VEGF）与结直肠癌（CRC）中VEGF受体（VEGF-R）肿瘤表达之间的关系仍不清楚。本研究旨在确定CRC患者血清VEGF浓度与肿瘤VEGF-R表达之间的关系。
方法
对连续1年接受择期结直肠手术的患者进行前瞻性研究。术前通过酶联免疫吸附测定法测定VEGF，通过免疫化学法测定VEGF-R3。
结果
初始样本包括134例诊断为CRC的患者。结果显示，即使存在混杂因素（性别、年龄、体重指数、肿瘤位置和手术方式），VEGF的血清值与VEGF-R3表达也存在显著关联（P < 0.001）。估计的效应量较高（η = 0.35）。
结论
CRC患者血清VEGF与肿瘤VEGF-R3表达显著相关。
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