Fotherby K J, Wraight E P, Neale G
Dept. of Gastroenterology, Addenbrooke's Hospital, Cambridge, U.K.
Scand J Gastroenterol. 1988 Mar;23(2):171-7. doi: 10.3109/00365528809103963.
An intestinal permeability test with a combination of 51Cr-EDTA and 14C-mannitol was performed under routine conditions on 176 occasions in 161 adult patients. Of these patients, 116 were under investigation for possible coeliac disease, 33 were known to have coeliac disease, and 12 had inflammatory bowel disease. Small-bowel biopsies were performed in 61 patients. Expressing the results as the ratio of the 6-h urinary recoveries of the two probes was as sensitive as (95%) but more specific for histologic mucosal abnormality (62% versus 46%) than measuring the urinary recovery of 51Cr-EDTA alone. All but two of the patients with active inflammatory bowel disease, whether Crohn's disease or ulcerative colitis, had an abnormal ratio. The 51Cr-EDTA/14C-mannitol intestinal permeability test with a 6-h urine collection is a rapid and simple test of small-intestinal function suitable for routine use.
在常规条件下，对161例成年患者进行了176次51铬-乙二胺四乙酸（51Cr-EDTA）和14碳-甘露醇（14C-甘露醇）联合的肠道通透性测试。这些患者中，116例正在接受乳糜泻可能性的检查，33例已知患有乳糜泻，12例患有炎症性肠病。61例患者进行了小肠活检。将结果表示为两种探针6小时尿回收率的比值，与单独测量51Cr-EDTA的尿回收率相比，对组织学黏膜异常同样敏感（95%），但特异性更高（62%对46%）。除两名患有活动性炎症性肠病（无论是克罗恩病还是溃疡性结肠炎）的患者外，其余患者的比值均异常。收集6小时尿液的51Cr-EDTA/14C-甘露醇肠道通透性测试是一种快速、简单的小肠功能测试，适合常规使用。
